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1

Effects of post-weaning social isolation and environmental enrichment on exploratory behavior and anxiety in Wistar rats

100%
Tanas L., Ostaszewski P., Iwan A.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr 1
Adverse early experience is generally regarded as a risk factor for both externalizing and internalizing behavioral disorders in humans. It can be modeled in rats by a post-weaning social isolation procedure. Effects of social isolation might possibly be ameliorated by environmental enrichment. In the current study, 24 male Wistar rats were divided post-weaning into four rearing conditions: control, environmental enrichment (EE), social isolation (SI) and a combination of the two experimental conditions; (EE+SI). Two observations of the effects of rearing conditions on the rate of social and object interactions were conducted during the juvenile and post-pubertal stages of development. The SI condition led to a marked increase of social interactions during the juvenile phase, but did not affect object interactions. The EE condition increased the level of social interactions during both the juvenile and post-pubertal measurements. The effects of early rearing conditions on adult exploratory behavior were less clear, with a significant difference between the groups obtained in one of three behavioral tests. Results suggest a general robustness in the development of adult exploratory behavior and anxiety when rats were exposed to early social isolation and provided brief opportunities for social play during the juvenile period. Further studies, aimed at distinguishing play-related protective factors serving against long-term adverse effects of juvenile social isolation, are suggested.
2
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Heavy metal content in environmental enrichment used for laboratory rodents

100%
Ochniewicz P., Karczmarczyk U., Sochaczewski L., Laszuk E., Garnuszek P.
Zeszyty Problemowe Postępów Nauk Rolniczych
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2019
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tom 597
3
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Impact of environmental enrichment on the productivity of Japanese quails

100%
Wengerska K., Ramankevich A., Rokicka K., Drabik K., Knaga S., Batkowska J.
Animal Science and Genetics
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2022
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tom 18
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nr 3
4

Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease

100%
Hannan A. J.
Acta Biochimica Polonica
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2004
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tom 51
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nr 2
Huntington's disease (HD) is an autosomal dominant disorder in which there is pro­gressive neurodegeneration producing motor, cognitive and psychiatric symptoms. HD is caused by a trinucleotide (CAG) repeat mutation, encoding an expanded polyglutamine tract in the huntingtin protein. At least eight other neurodegenerative diseases are caused by CAG/glutamine repeat expansions in different genes. Recent evidence suggests that environmental factors can modify the onset and progression of Huntington's disease and possibly other neurodegenerative disorders. This re­view outlines possible molecular and cellular mechanisms mediating the polyglutamine-induced toxic 'gain of function' and associated gene-environment interactions in HD. Key aspects of pathogenesis shared with other neurodegenerative diseases may include abnormal protein-protein interactions, selective disruption of gene expression and 'pathological plasticity' of synapses in specific brain regions. Recent discoveries regarding molecular mechanisms of pathogenesis are guiding the development of new therapeutic approaches. Knowledge of gene-environment interactions, for example, could lead to development of ‘enviromimetics’ which mimic the beneficial effects of specific environmental stimuli. The effects of environmental enrichment on brain and behaviour will also be discussed, together with the general implications for neuroscience research involving animal models.
5

Behaviour and welfare of tom turkeys under enriched husbandry conditions

84%
Berk J., Hinz T.
Annals of Animal Science. Supplement
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2002
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nr 1
6

Effect of a veranda on behaviour, health and performance of male turkeys

67%
Berk J., Wartemann S.
Animal Science Papers and Reports. Supplement
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2005
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tom 23
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nr 1
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