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Expression of endothelin-1, and endothelin A and B receptors in portal hypertensive esophagus of rats

100%

Ohta M., Pai R., Kawanaka H., Ma T., Sugimachi K., Sarfeh I. J., Tarnawski A. S.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 1

2

Cerebral angiogenesis after subarachnoid hemorrhage (SAH) and endothelin receptor blockage with BQ-123 antagonist in rats

100%

Josko J., Hendryk S., Jedrzejowska-Szypulka H., Slowinski J., Gwozdz B., Lange D., Snietura M., Zwirska-Korczala K., Jochem J.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 2

3

Pathways of glomerular toxicity of cyclosporine-A: an "in vitro" study

84%

Castello L., Sainaghi P. P., Bergamasco L., Letizia C., Bartoli E.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 4

Background/Aims. Knowledge of renal toxicity of cyclosporine-A (CyA) is clouded by multiple effects on different glomerular and tubular cells and on kidney and systemic hemodynamics. To focus on glomerular action of CyA we used glomeruli isolated in vitro, with the aim of dissecting the effects on recruitment of glomerular vasoconstricting systems, like endothelin-1 (ET) and angiotensins (AI and AII). Methods. We studied the pathways of CyA damage on pig glomeruli isolated in vitro with the technique of sieving through mesh filters of different sizes, and incubated in an appropriate culture medium. The supernatant was sampled at different time intervals to measure ET, AI and AII concentrations upon addition of ET 10-12 or CyA 4·10-7 M, with or without either selective endothelin receptor A (ETA) or B (ETB), or unselective ETA-ETB receptor inhibitors. Results. CyA increased ET concentration (from 9.7±0.3 to 11.4±0.4 pg·ml-1, p<0.002), and the added ET released AI in the medium (from 26.6±4.7 to 39.1±4.6 pg·ml-1, p<0.05) when ETB receptors were blocked. In contrast, CyA stimulated angiotensins release independent of ET receptors blockade, hence, irrespective of ET concentration in the medium, from 26.6±4.7 to 38.0±2.1 pg·ml-1 for AI, p<0.05, and from 12.3±1.0 to 14.8±0.9 pg·ml-1 for AII, p<0.05. Conclusion. CyA releases ET and angiotensins independently by a direct action. Glomerular CyA toxicity might be mediated by recruitment of vasoconstricting peptides and modulated by relative ETA and ETB receptor occupancy.

4

Immunoreactivities of eNOS, ET-1 and ETB-R in blood vessels of the uterine mesometrium during the estrous cycle in the pig

59%

Andronowska A., Doboszynska T.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 2

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Folia Histochemica et Cytobiologica

1 Andronowska A.

1 Bartoli E.

1 Bergamasco L.

1 Castello L.

1 Doboszynska T.

1 Gwozdz B.

1 Hendryk S.

1 Jedrzejowska-Szypulka H.

1 Jochem J.

1 Josko J.

1 Kawanaka H.

1 Lange D.

1 Letizia C.

1 Ma T.

1 Ohta M.

1 Pai R.

1 Sainaghi P. P.

1 Sarfeh I. J.

1 Slowinski J.

1 Snietura M.

1 Sugimachi K.

1 Tarnawski A. S.

1 Zwirska-Korczala K.

1 2005

1 2002

1 2001

1 2000

Expression of endothelin-1, and endothelin A and B receptors in portal hypertensive esophagus of rats

Cerebral angiogenesis after subarachnoid hemorrhage (SAH) and endothelin receptor blockage with BQ-123 antagonist in rats

Pathways of glomerular toxicity of cyclosporine-A: an "in vitro" study

Immunoreactivities of eNOS, ET-1 and ETB-R in blood vessels of the uterine mesometrium during the estrous cycle in the pig