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1

In vivo study of the oestrogenic activity of milk

100%
Radko L., Posyniak A.
Journal of Veterinary Research
|
2021
|
tom 65
|
nr 3
2
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Health risk of exposure to bisphenol A (BPA)

100%
Konieczna A., Rutkowska A., Rachon D.
Roczniki Państwowego Zakładu Higieny
|
2015
|
tom 66
|
nr 1
Bisphenol A (BPA) belongs to chemicals that are produced in large quantities worldwide. It is commonly used as monomer in polycarbonate synthesis, plasticizer in the production of epoxy resins, as well as an additive for the elimination of surfeit of hydrochloric acid during the polyvinyl chloride (PVC) production. BPA is not only used in the production of plastics intended to a direct contact with food, including plastic packaging and kitchenware, but also in inner coatings of cans and jar caps. There are various routes of human exposure to this substance such as oral, by inhalation and transdermal. The main sources of exposure to BPA include food packaging and dust, dental materials, healthcare equipment, thermal paper, toys and articles for children and infants. BPA is metabolized in the liver to form bisphenol A glucuronide and mostly in this form is excreted with urine. Due to its phenolic structure BPA has been shown to interact with estrogen receptors and to act as agonist or antagonist via estrogen receptor (ER) dependent signalling pathways. Therefore, BPA has been shown to play a role in the pathogenesis of several endocrine disorders including female and male infertility, precocious puberty, hormone dependent tumours such as breast and prostate cancer and several metabolic disorders including polycystic ovary syndrome (PCOS). Because of the constant, daily exposure and its tendency to bio-accumulation, BPA seems to require special attention such as biomonitoring. This observation should include clinical tests of BPA concentration in the urine, which is not only one of the best methods of evaluation of the exposure to this compound, but also the dependence of the daily intake of BPA and the risk of some endocrine disorders.
3

Comparing methods of 17alpha-ethinylestradiol (EE2) determination in surface water

100%
Czerwonka G., Kaca W.
Polish Journal of Environmental Studies
|
2012
|
tom 21
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nr 4
We compared methods of determination of 17α-ethinyloestradiol (EE2) in surface water in Kielce, Poland. EE2 plays a role as a contraception agent and it is commonly used as an active agent in contraception pills. During studies three methods of EE2 determination were checked: TLC, HPLC, and ELISA assay. Samples of contaminated water were taken from eight points on four rivers crossing Kielce city, tap water, and sludge in a sewage treatment plant (STP). Assays revealed that EE2 is present in river water in amounts of 3.2 ng/Lto 6.29 ng/L. The EE2 removal process in STP is ineffective, removings only 1.3%. EE2 was not detected in Kielce's tap water. No correlation between fecal microbial contamination and EDS presence was determined.
4

Endocrine disruptors - ecotoxicological assays

100%
Lebkowska M., Zaleska-Radziwill M.
Archiwum Ochrony Środowiska
|
2007
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tom 33
|
nr 3
5
Content available remote

Inhibitory effect of octyl-phenol and bisphenol A on calcium signaling in cardiomyocyte differentiation of mouse embryonic stem cells

84%
Lee J.-H., Yoo Y.-M., Jung E.-M., Ahn C., Jeung E.-B.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 3
6

The influence of the environmental endocrine disrupting compounds (EDCs) 17alpha-ethinyl estradiol and bisphenol A on the development of gonads in Xenopus laevis, Bufo viridis and Hyla arborea

84%
Rozenblut-Koscisty B., Ogielska M., Tamschick S., Lehmann A., Lymberakis P., Hoffmann F., Lutz I., Schneider R. J., Kekenj D., Gajewski F., Kruger A., Kloas W., Stock M.
Acta Biologica Cracoviensia. Series Botanica. Supplement
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2016
|
tom 58
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nr 1
7

Nonylphenol and 4-tert-octylphenol in the Gulf of Gdansk coastal zone

84%
Staniszewska M., Falkowska L.
Oceanological and Hydrobiological Studies
|
2011
|
tom 40
|
nr 2
8

Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine

67%
Wesierska-Gadek J., Schreiner T., Maurer M., Waringer A., Ranftler C.
Cellular and Molecular Biology Letters
|
2007
|
tom 12
|
nr 2
Estrogens play an important role in the growth and terminal differentiation of the mammary gland. Prolonged exposure to estrogens seems to predispose women to breast cancer. It recently became evident that not only the intrinsic hormonal status but also external factors such as the occurrence of pharmaceuticals and chemicals with hormone activity in the environment may put women at greater risk of developing breast cancer. We focused on the interference of endocrine disruptors in breast cancer therapy. We observed that phenol red added to the culture medium strongly promoted the cell proliferation and cell cycle progression of human cells expressing the estrogen receptor, and affected their susceptibility to chemotherapy.
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