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Analysis of a fusion between rat glioma cells and biomimetic liposomes with encapsulated diamond nanoparticles or curcumin

100%

Strojny B., Grodzik M., Sawosz E., Gromadka M.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

2016

tom 55[2]

Analysis of a fusion between rat glioma cells and biomimetic liposomes with encapsulated diamond nanoparticles or curcumin. Liposomes are used as carriers for different bioactive agents, both hydrophilic, which are encapsulated in water core of the liposome, and hydrophobic, which are entrapped within liposome walls. The walls are built from phospholipid bilayer, therefore their structure resembles cell membrane. It was hypothesized that if the wall is made of set of lipids typical for a cell, the liposome will be eagerly consumed by the cell. We performed the experiments using C6 rat glioma cells as an example, since central nervous system cells are extremely rich in lipids, including the unique ones. Since all cancer cells have high proliferation potential, they need to absorb precursors to build cell membrane around new cells, therefore such biomimetic liposomes may be one of the most effective way to deliver anticancer agents into the cell. Analysis of physicochemical properties of obtained liposomes, as well as in vitro tests, showed that obtaining such liposomes is possible and that the liposomes are biocompatible, stable carrier both for hydrophilic and hydrophobic agents. Encapsulation of diamond nanoparticles did not affect the liposomes, whereas entrapping of curcumin, which is a spice known in traditional Asian medicine for its anticancer properties, significantly increased its activity. Obtained results showed that biomimetic liposomes can be effective, individually-tailored carriers for bioactive agents.

Targeting liposomes to the endothelium

100%

Kamps J. A. A. M., Bartsch M., Asgeirsdottir S. A., Morselt H. W. M., Scherphof G. L., Molema G.

Cellular and Molecular Biology Letters

2005

tom 10

nr Suppl.

Ograniczanie wyników

1 Annals of Warsaw University of Life Sciences - SGGW. Animal Science

1 Cellular and Molecular Biology Letters

1 Asgeirsdottir S. A.

1 Bartsch M.

1 Grodzik M.

1 Gromadka M.

1 Kamps J. A. A. M.

1 Molema G.

1 Morselt H. W. M.

1 Sawosz E.

1 Scherphof G. L.

1 Strojny B.

1 2016

1 2005

Wyniki wyszukiwania

Analysis of a fusion between rat glioma cells and biomimetic liposomes with encapsulated diamond nanoparticles or curcumin

Targeting liposomes to the endothelium