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1
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Dyspnea and quality of life in patients with pulmonary fibrosis after six weeks of respiratory rehabilitation

100%
Jastrzebski D., Gumola A., Gawlik R., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 4
139-148
The aim of the study was to estimate the level of dyspnea and quality of life in patients with pulmonary fibrosis after 6 weeks' respiratory rehabilitation. The study comprised of 31 patients (F/M-12/19) with interstitial lung diseases (21 with idiopathic interstitial pneumonia, 4 with lung fibrosis due to allergic alveolitis, 4 with lung fibrosis due to collagenosis, 2 with lung fibrosis due to silicosis) who successfully finished the rehabilitation program. Each patient underwent an intensive (every day for 30 min) inpatient pulmonary rehabilitation program of an average length of 4 wk, continued later at home for up to 12 wk. The program consisted of respiratory muscle training and bicycle riding to the limits of the patient's tolerance. Dyspnea (MRC, OCD, BDI and Borg scale) and the quality of live (SF-36, St. George's Respiratory Questionnaire) were assessed at the time of admission and discharge. Rehabilitation caused dyspnea sensation to diminish (Borg scale: 2.97 before vs. 2.19 after). Some domains of the quality of life in SF-36 questionnaire (Role-Physical 40.6 vs. 60.2) and St. George's Respiratory Questionnaire (activity: 52 vs. 45, impact 47 vs. 40 and total 47 vs. 42) also were improved compared with the pre-rehabilitation results. We conclude that 12 weeks of combined inpatient and home-based rehabilitation programme improves the quality of live and sensation of dyspnea in patients with interstitial lung disease, despite changes in pulmonary function tests.
2
Content available remote

Tracheobronchial amyloidosis - bronchoscopic diagnosis and therapy of an uncommon disease: a case report

67%
Brill A. K., Woelke K., Schadlich R., Weinz C., Laier-Groeneveld G.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
3
Content available remote

Heparin-induced thrombocytopenia in a patient with massive lung embolism and left-sided pneumonia: a case report

67%
Doboszynska A., Rozek M., Swietlik E., Tomaszewska I.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
4
Content available remote

Pleuritis as the first symptom of pulmonary embolism: a case report

67%
Doboszynska A., Koc M., Koc K., Swietlik E., Sosnowska E., Tomaszewska I.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
5

A review of asthma genetics: gene expression studies and recent candidates

67%
Malerba G., Pignatti P. F.
Journal of Applied Genetics
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2005
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tom 46
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nr 1
Recent evidence indicates an important role of inflammation pathways, airways remodeling and epithelium activation in asthma genetics. In particular, transcriptome studies have detected differentially expressed genes involved in eosinophil apoptosis, the arginase pathway, response to allergens or interleukins, and to inhaled corticosteroids Candidate gene and genome wide studies have localized genetic regions involved in the disease, such as the A1AK and CLCA1 genes (chromosome 1), IL-1RN and DPP10 (2q14), HLA-G and TNF-α(6p21), GPRA (7p14), FcεRI and GSTP1 (11q13), NOSI, IFNG, STAT6, VDR, and other genes (12q13-26 ), PHF11 and flanking genes (13q14), AACT and PTGDR (14q), and ADAM33 (20p13). The role of these and other genetic determinants has to be confirmed in future, preferably longitudinal, studies.
6
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Content available

Cysteinyl-leukotriene receptors in pulmonary vessels

67%
Walch L., Norel X., Gascard J. P., Brink C.
Journal of Physiology and Pharmacology
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1999
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tom 50
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nr 4
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