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Transcription factors as targets of anticancer drugs

100%

Gniazdowski M., Czyz M.

Acta Biochimica Polonica

1999

tom 46

nr 2

Several general and gene- and cell-selective transcription factors are required for specific transcription to occur. Many of them exert their functions through specific contacts either in the promoter region or at distant sequences regulating the initiation. These contacts may be altered by anticancer drugs which form non-covalent complexes with DNA. Covalent modifications of DNA by alkylating agents may prevent transcription factors from recognizing their specific sequences or may constitute multiple "unnatural" sites in DNA which attract the factors thus decreasing their availability in the cell. The anticancer drug-transcription factor interplay which is based on specific interactions with DNA may contribute to pharmacological properties of the former and provide a basis for the search for new drugs.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Czyz M.

1 Gniazdowski M.

1 1999

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Transcription factors as targets of anticancer drugs