Wyniki wyszukiwania

1

Effect of dexpanthenol on colonic anastomosis healing in rats

100%

Ermutlu C. S., Erkilic E. E., Kilic E., Kirmizigul A. H., Dag S., Ogun M., Baran V., Merhan O.

Medycyna Weterynaryjna

|

2018

|

tom 74

|

nr 11

The purpose of this study was to perform the clinical, histopathologic and biochemical evaluation of the effects of intraperitoneally (IP) administered dexpanthenol (dxp) on colonic anastomosis healing in rats. The study was conducted on a total of 28 rats divided into four groups comprising seven rats each. Group I was designated as the control group, group II as the dxp group, group III as the anastomosis group, and group IV as the anastomosis + dxp group. The groups were compared in terms of intestinal bursting pressure, adhesion formation, nitric oxide (NO) and malondialdehyde (MDA) levels, total antioxidant capacity (TAC) and total oxidant capacity (TOC) in blood and intestinal homogenates, as well as histopathologic findings. Dxp decreased adhesion formation (6 rats in group III and 4 rats in group IV). Mean bursting pressures were higher in the dxp groups than in the other groups (group II = 254.3 ± 42.1 mmHg, group IV = 109.3 ± 34.5 mmHg). Moreover, there was a remarkable decrease in the levels of NO and MDA and in blood oxidative stress parameters in the dxp groups. The results suggest that dxp increased intestinal bursting pressure by accelerating healing in the anastomosis line and decreased adhesion formation, positively affecting healing. Dexpanthenol, which was found to have positive effects in the experimental rat model, can be introduced into clinical practice.

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Treatment of seborrheic dermatitis: The efficiency of sertaconazole 2% cream vs. tacrolimus 0.03% cream

84%

Goldust M., Rezaee E., Raghifar R., Hemayat S.

Annals of Parasitology

|

2013

|

tom 59

|

nr 2

The treatment of seborrheic dermatitis (SD) includes topical antifungal agents to eradicate Malassezia spp. corticosteroids to treat the inflammatory component of the disease, and keratolytics to remove scale and crust. The aim of this study was to compare the efficiency of sertaconazole 2% cream and tacrolimus 0.03% cream in the treatment of seborrheic dermatitis. In this clinical trial study, sixty patients suffering from SD were studied. Thirty patients received local sertaconazole 2% cream with a recommendation to use the cream twice a day for 4 weeks. In the control group, thirty patients received tacrolimus 0.03% cream twice a day for four weeks. At the time of referral, and 2 and 4 weeks after first visit, the patients were examined by a dermatologist to check the improvement of clinical symptoms. The mean ages of the sertaconazole and tacrolimus groups were 30.98 ± 12.24 and 34.67 ± 10.82, respectively. The highest level of satisfaction (90%) was observed 28 days after sertaconazole use. Only 83.3% satisfaction was noted in the tacrolimus group. The relationship between patient satisfaction and sertaconazole 2% cream receive in 28th day was significant (P=0.006). Sertaconazole 2% cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis.

3

Effect of verapamil on chemiluminescence of peripheral blood neutrophils during hemodialysis in chronic uremic patients

84%

Pawlicki L., Tchorzewski H., Trznadel K., Luciak M., Kantorski J., Pokoca L.

Archivum Immunologiae et Therapiae Experimentalis

|

1989

|

tom 37

|

nr 1-2

4

Effect of disodium cromoglycate on deuterium oxide-induced degranulation of human eosinophils in allergic asthmatic patients in vitro

67%

Palczynski C., Gorski P., Grzegorczyk J.

Archivum Immunologiae et Therapiae Experimentalis

|

1989

|

tom 37

|

nr 1-2

5

Effect of Methisoprinol and KLP-602 on the development of immunocompetent organs and selected biochemical indices of the allantoic fluid of chicken embryos

67%

Malaczewska J., Rotkiewicz Z., Siwicki A. K.

Polish Journal of Veterinary Sciences

|

2003

|

tom 06

|

nr 3 Suppl.

6

Chronotherapy in veterinary medicine

67%

Giudice E., Pugliese A., Piccione G.

Medycyna Weterynaryjna

|

2006

|

tom 62

|

nr 03

243-247

Most clinical variables in animals follow biological rhythms which have a mathematical function defined by cosmic-climatic rhythms. Chronophysiology, chronopathology, chronopharmacology and chronotherapy have common elements but are frequently studied in isolation, thus making it difficult for a global understanding of clinical chronobiology as a unitary and well-defined discipline. The physiological effects of a drug depend not only on its molecular structure but also on the time-pattern of its administration. One of the main reasons for the importance of temporal patterns in drug activity is biological rhythm, and in particular that of the circadian period. These rhythms affect most physiological functions as well as drug metabolism, clearance, and dynamic processes that may alter drug availability and target cell responsiveness in relation to biological time. Chronotherapy studys the optimal level of drug effects and/or the minimizing of its toxicity by timing medications in relation to biological rhythms. This review focuses on medical chronobiology, which is much more technical since it only studies those aspects of clinical chronobiology having a health-care impact on daily practice.

7

The effect of herbal remedy on the development of Trichinella spiralis infection in mice

67%

Bany J., Zdanowska D., Zdanowski R., Skopinska-Rozewska E.