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1
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The renal actions of oxytocin in the conscious rat

100%
Windle R. J., Forsling M. L.
Journal of Physiology and Pharmacology
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1991
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tom 42
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nr 4
The renal actions of oxytocin were studied in the conscious unrestrained rat infused with 0.077 M saline at a rate of 150 µl/min. During the control period volume and sodium excretion reached stable equilibria, the rates being equal to those infused. Administration of oxytocin at 200 pmol/min produced plasma oxytocin levels of 26.0±2.1 pmol/1 and caused a significant diuresis and natriuresis. Renal responses could also be seen with a lower dose of 30 pmol/min which produced plasma levels of 5.1 ±0.5 pmol/1 while a dose of 15 pmol/min which produced no significant increase in the plasma oxytocin had no renal effect. It appears that oxytocin has a natriuretic action in concentrations within the physiological range.
2

Stereochemistry of insect kinin tetrazole analogues and their diuretic activity in crickets

100%
Nachman R. J., Coast G. M., Kaczmarek K., Wiliams H. J., Zabrocki J.
Acta Biochimica Polonica
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2004
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tom 51
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nr 1
Insect kinin analogues of the sequence Phe-Phe-Ψ[CN4]-Ala-Trp-Gly-NH2 containing (L-Phe2,L-Ala3) and (L-Phe2,D-Ala3) stereochemical variants of the tetrazole moiety, a mimic of the type VI -turn, demonstrate significant agonist and partial antagonist activity, respectively, in a cricket diuretic bioassay. A comparison of the solution conformations of these two stereochemical variants indicates a structural basis for their divergent bioactivities. The (D-Phe2,D-Ala3) stereochemical variant was synthesized and found to demonstrate significant agonist activity. The results further define stereochemical requirements for the diuretic activity of insect kinins in crickets and provide valuable information for the design of biostable analogues capable of disrupting digestive and diuretic processes in pest insects.
3
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Dissociation between the effects of P1,P4-diadenosine tetraphosphate (Ap4A) on renal haemodynamics and tubular function in anaesthetized rats

84%
Jankowski M., Angielski S., Szczepanska-Konkel M.
Journal of Physiology and Pharmacology
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2008
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tom 59
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nr 1
Previous studies from our laboratory have reported a marked reduction in glomerular filtration rate (GFR) and sodium reabsorption in renal proximal tubule during intravenous infusion of P1,P4-diadenosine tetraphosphate (Ap4A) at dose of 1.0 µmol/kg + 10 nmol/kg/min (i.v., injection followed by infusion) in anaesthetized Wistar rats. In the present study, the changes of GFR and urine sodium excretion were investigated in response to systemic infusion of Ap4A at different doses. Ap4A at dose of 0.1 µmol/kg + 1.0 nmol/kg/min did not change GFR and sodium urinary excretion whereas 2-fold higher dose produced significant (3.4-fold) increase in sodium excretion without changes in GFR. Significant but transient reduction in GFR by ~21% was observed during infusion of Ap4A at dose of 0.5 µmol/kg + 5.0 nmol/kg/min. Higher doses of Ap4A (1.0 µmol/kg + 10 nmol/kg/min and 2.0 µmol/kg + 20 nmol/kg/min) produced sustained reduction in GFR and marked natriuresis. Our results suggest that tubular sodium transport systems are more sensitive to Ap4A than systems involved in GFR regulation.
4
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Identification of a CAPA-PVK [Ixori-PVK] from single cells of the gulf Gulf Coast tick, Amblyomma maculatum

67%
Neupert S., Russell W. K., Russell D. H., Strey O. F., Teel P. D., Strey A., Nachman R. J.
Pestycydy
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2008
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nr 1-2
67-73
MALDI-TOF/TOF tandem mass spectrometry has been applied to determine the complete sequence of a CAPA-PVK in the Gulf Coast tick, Amblyomma maculatum. Single cell analysis allowed the identification of the amino acid sequence of Ixori-PVK (PALIPFPRV-NH2), a periviscerokinin which had previously been identified from two other ticks, Ixodes ricinus and Boophilus microplus. The identification indicates greater conservation of sequence for the CAPA-PVK/CAP2b family in ticks as compared with insects. Side-chain fragmentation experiments provided data to distinguish between Leu/Ile ambiguities. The tick CAPA peptide shows a high sequence homology with other members of the insect periviscerokinin/ CAP2b peptides, which are associated with the regulation of critical physiological processes such as diuresis. Thus, the identification of this neuropeptide will provide the experimental basis to better understand regulation of water balance in these arthropods, providing a potential opportunity to develop neuropeptide-based control strategies against these livestock pests.
5

Evidence for a CAP2b-like anti-diuretic hormone in the blood-gorging insect, Rhodnius prolixus

67%
Paluzzi J.-P., Orchard I.
Pestycydy
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2005
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nr 3
141-145
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The mechanism of Naplus, Kplus -ATPase inhibition by atrial natriuretic factor in rat renal medulla

67%
Beltowski J., Gorny D., Marciniak A.
Journal of Physiology and Pharmacology
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1998
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tom 49
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nr 2
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