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Neuroendocrine cells in the nasal mucosa - preliminary report

100%
Sieskiewicz A., Olszewska M., Olszewska E., Garbowicz M., Trojan S., Chyczewski L., Rogowski M.
Folia Histochemica et Cytobiologica
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2007
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tom 45
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nr 2
2
Content available remote

Quantitative characteristics of somatostatin-like cells in the stomach of uraemic rats

84%
Kasacka I.
Journal of Physiology and Pharmacology
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2006
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tom 57
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nr 1
Metabolic disorders induced by impairment of renal parenchyma functions affect the activity of the endocrine cells of the APUD system, which are of importance in the intrinsic regulatory system in the digestive tract. For this reason, the author decided to investigate the behaviour of neuroendocrine cells in experimental uraemia, taking somatostatin-producing cells as an example. The aim of the present study was to examine the number and distribution of somatostatin-containing cells in the pylorus of rats with uraemia. Segments of the gastric pylorus were collected 1, 2 and 4 weeks after nephrectomy. Paraffin-embedded sections were stained with H+E and by silver impregnation. To identify the neuroendocrine cells, on immunohistochemical reaction was performed with a specific antibody against somatostatin. It was found that the number of ST-immunoreactive cells in the stomach of the rats significantly decreased one week after nephrectomy and then considerably increased two and four weeks after the uraemia-inducing surgery as compared with the values in the control animals. The results can be regarded as a morphological manifestation of the hyperreaction of somatostatin-producing endocrine cells in the rat stomach to disorders in the internal environment of the body induced by impairment of renal parenchyma function.
3
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Can doxazosin inhibit the hypertension-induced changes of endocrine cells in the stomach of spontaneously hypertensive rats?

67%
Kasacka I., Majewski M.
Journal of Physiology and Pharmacology
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2008
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tom 59
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nr 1
We have previously shown that the endocrine cells in the stomach increase in number in spontaneously hypertensive rats (SHR) that suggests that the hypertension has an influence on the intrinsic regulatory system by endocrine cells control in the stomach of rats. The aim of the present study is to find differences in the density of neuroendocrine (NE) cells of stomach rats and composition in doxazosin treated SHR compared to untreated animals. Fragments of the pyloric region were collected at 12 weeks of age. Paraffin-embedded sections were stained with H+E and by silver impregnation. To identify NE cells, immunohistochemical reaction (IR) was performed with the use of a specific antibody against somatostatin, gastrin, serotonin and chromogranin. It was revealed that the distribution density of IR-endocrine cells all searched types was considerable lower in the pyloric mucosa of hypertension animals treated with doxazosin compared to SHR untreated and was on level healthy rats. The present study demonstrated that doxazosin inhibit the hypertension-induced changes of endocrine cells in the stomach of SHR.
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