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Assessing knowledge of physical activity benefits in diabetic patients

100%

Junger J., Drackova D., Bukova A., Junger A., Kuchelova Z.

Health Problems of Civilization

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2020

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tom 14

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nr 2

Background. The aim of this work was to examine the awareness of patients with diabetes mellitus (DM) on the importance of physical activity (PA) in the prevention and treatment of their disease. Material and methods. The survey was completed by 178 respondents (47.3% women, 52.7% men), of whom 69.1% were dependent on exogenous insulin. Data was collected in April 2019 via a questionnaire given to patients at the Department of Diabetology and Internal Medicine at the Louis Pasteur University Hospital in Košice, Slovakia. Results. More than half of the respondents admitted having insufficient information about their health condition, and a similar proportion felt lack of knowledge regarding exercise for their illness. As many as 69.1% of the patients reported inadequate help by their health care providers with regard to the do’s and dont’s of their disease, and 41.9% of respondents reported having no knowledgeable health care provider with whom to share their concerns. Conclusions. Based on the results obtained, it is concluded that a substantial number of DM patients do not have adequate information about their health condition and how to improve it. On the other hand, nearly two-thirds of participants recognize that regular physical activity (PA) is an option to achieve positive changes.

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Glycosaminoglycans of human serum and their alterations in diabetes mellitus

100%

Kozma E. M., Olczyk K., Glowacki A., Komosinska K., Sonecki P., Najmiec T., Jazwiec M.

Acta Biochimica Polonica

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1996

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tom 43

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nr 3

Human serum contains several glycosaminoglycans (GAGs), mainly chondroitin sulphates and significantly less of heparan sulphate + heparin and dermatan sulphate. The non-insulin-dependent diabetes mellitus (with vascular complications) was associated with a significant increase in total serum GAG concentration, mainly of chondroitin sulphates and dermatan sulphate, with a simultaneous decrease in heparan sulphate + heparin level. These alterations were much more evident in patients with poor metabolic control. Hyaluronic acid (undetectable in healthy subjects and in patients with good metabolic control) appeared only in trace amounts in poorly controlled diabetic individuals. The obtained data allow to conclude that the diabetes mellitus-associated disturbances in tissue GAG metabolism lead to significant alterations in serum GAG composition.

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Immunotherapy of type 1 diabetes

84%

Li L., Yi Z., Tisch R., Wang B.

Archivum Immunologiae et Therapiae Experimentalis

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2008

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tom 56

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nr 4

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Are we helping or harming our insulin-treated diabetic patients during ambulatory treatment?

67%

Szczesniak G., Dziemidok P., Paprzycki P.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

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nr 2

Introduction. Correctness of insulin treatment depends on both the experience and skills of the doctor and knowledge and behaviour of the patient. Objective. Evaluation the adequacy of insulin doses administered to diabetes patients in ambulatory conditions. Material and methods. The treatment of 59 patients hospitalized in the Diabetology Ward was evaluated at admission, discharge and 3 months after hospitalization. Results. The mean daily doses of insulin significantly differed at times of evaluation and were: 53.90, 39.31 and 43.34 units, respectively (p≈0.000001). A significant reduction of body weight, 90.86 vs. 88.25 kg (p≈0.000001), was obtained only during hospitalization, and was maintained 3 months after discharge (87.86 kg). Significant differences were also noted in the body mass index (33.44 vs. 32.48 vs. 32.37 kg/m2, p≈0.000001). The change in waist circumference was not statistically significant (107.87 vs. 104.89 cm; p≈0.06). A decrease in the number of hypoglycaemia episodes was observed, but were statistically insignificant (25 vs. 23; p≈0.7). Three months after hospitalization an insignificant decrease of HbA1c level was noted (8.41% vs. 8.03%; p≈0.07). Conclusions. During treatment in the Diabetology Ward the procedure of choice was more frequently a reduction than an increase in insulin doses. This management led to the reduction of the patients’ body weight, improvement of glycaemia, without any significant effect on the diabetes control determined by the HbA1c level.

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Morphological and morphometric studies of the aorta, pulmonary trunk, and heart of streptozotocin-induced diabetic Wistar rats

67%

Komolafe O. A., Adeyemi D. O., Adewole O. S., Obuotor E. M., Abiodun A. A.

Folia Morphologica

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2009

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tom 68

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nr 4

207-214

Micro-anatomical changes in the aorta, pulmonary trunk, and left ventricle of Wistar rats were studied after the administration of streptozotocin. Twenty adult Rattus norvegicus were randomly assigned into two groups (control and diabetic) of ten rats each. Diabetes mellitus was experimentally induced in the diabetic group of rats by daily intra-peritoneal administration of multiple doses of 40 mg/kg streptozotocin dissolved in 0.1 M sodium citrate buffer for five consecutive days. The control group was given the equivalent volume of citrate buffer. The animals were monitored for four weeks after streptozotocin administration. Post sacrifice, the left ventricle, aorta, and pulmonary trunk were excised, weighed, and fixed by immersion in 10% formol saline. The tissues were processed for paraffin embedding, and sections of 6 µm thickness were produced and stained with H & E for general histological observations, and Verhoeff-van Gieson elastic fibre stain to demonstrate elastic fibres in these cardiovascular structures. The data obtained were analyzed with descriptive and inferential statistics. Histopathological and morphometric examinations of the stained sections showed a significant increase in the thickness of the tunica intima of aorta (t = –7.49; df = 9; p < 0.05) and pulmonary trunk (t = –10.81; df = 9; p < 0.05) in diabetic rats (14.59 ± 1.189 μm and 11.307 ± 0.863 mm, respectively) when compared to that of the control group (3.62 ± 0.353 μm and 3.22 ± 0.244 μm, respectively). In addition, the distribution of elastic and collagen fibres was sparse in the hearts of the diabetic group when compared to that of the control group. The findings of this study demonstrated that diabetes mellitus might cause some alterations in the microanatomy of cardiovascular structures. (Folia Morphol 2009; 68, 4: 207–214)

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Insulin impairs the anticonvulsive activity of carbamazepine against maximal electroshock-induced seizures in mice

67%

Alaraj M., Pieniak M., Kowalczyk M., Kosinska I.

Acta Neurobiologiae Experimentalis

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1998

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tom 58

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nr 4

Ograniczanie wyników

Assessing knowledge of physical activity benefits in diabetic patients

Glycosaminoglycans of human serum and their alterations in diabetes mellitus

Immunotherapy of type 1 diabetes

Are we helping or harming our insulin-treated diabetic patients during ambulatory treatment?

Morphological and morphometric studies of the aorta, pulmonary trunk, and heart of streptozotocin-induced diabetic Wistar rats

Insulin impairs the anticonvulsive activity of carbamazepine against maximal electroshock-induced seizures in mice