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1
Content available remote

Ongoing pain in streptozotocin model of diabetes in the rat: correlation with cutaneous chemonociception

100%
Gao Z., Wei H., Chen Z., Jalava N., Koivisto A., Petrovaara A.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 6
2
Content available remote

Quercetin in association with moderate exercise training attenuates injuries induced by experimental diabetes in sciatic nerves

100%
Chis I. C., Clichici A., Nagy A. L., Oros A., Catoi C., Clichici S.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 6
3

Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor beta1 and its activation by thrombospondin-1

100%
Yevdokimova N. Y.
Acta Biochimica Polonica
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2006
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tom 53
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nr 2
The dysregulation of the metabolism of glycosaminoglycan and protein components of extracellular matrix (ECM) is a typical feature of diabetic complications. High glucose-induced enrichment of ECM with hyaluronan (HA) not only affects tissue structural integrity, but influences cell metabolic response due to the variety of effects depending on the HA polymer molecular weight. TSP-1-dependent activation of TGFβ1 axis is known to mediate numerous matrix disorders in diabetes, but its role concerning HA has not been studied so far. In this work we demonstrated that 30 mM d-glucose increased the incorporation of [3H]glucosamine in high-molecular-weight ( > 2000 kDa) HA of medium and matrix compartments of human mesangial cultures. Simultaneously, the synthesis of HA with lower molecular weight and HA degradation were not altered. The cause of the increased high-molecular-weight HA synthesis consisted in the up-regulation of hyaluronan synthase (HAS) 2 mRNA without alterations of the expression of HAS3, which generates HA of lower molecular weight. d-Glucose at 30 mM also stimulated the production of transforming growth factor β1 (TGFβ1), the excessive activation of which was determined by the up-regulation of thrombospondin-1 (TSP-1). The blockage of TGFβ1 action either by neutralizing anti-TGFβ1 antibodies or by quenching the TGFβ1 activation (with TSP-1-derived synthetic GGWSHW peptide) abolished the effect of high glucose on HAS2 mRNA expression and normalized the synthesis of HA. Exogenous human TGFβ1 had the same effect on HAS2 expression and HA synthesis as high glucose treatment. Therefore, we supposed that TSP-1-dependent TGFβ1 activation is involved in the observed high glucose effect on HA metabolism. Since high-molecular-weight HA polymers, unlike middle- and low-molecular weight HA oligosaccharides, are known to possess anti-inflammatory and anti-fibrotic functions, we suppose that the enrichment of mesangial matrix with high-molecular-weight HA may represent an endogenous mechanism to limit renal injury in diabetes.
4

Diabetic neuropathy and new options of its detection [case reports]

100%
Jilek M., Martinik K., Tosnerova V.
Żywienie Człowieka i Metabolizm
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2007
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tom 34
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nr 1-2
Postural regulation means adopting and maintenance of stable posture of the body in gravitational field earth. Neuropathic leg (neuropathy) is the insult of nerves going into the legs. It affects not only motor, but rgely sensitive nerves. Pursuant pilot research we can claim that the level of affection with diabetic uropathy influences the achievement in postural regulation in the negative. The disability of only sensitive rves faces to deterioration of postural regulation in front plateau (lateral balance).
5
Content available remote

The influence of autonomic neuropathy on cough reflex sensitivity in children with diabetes mellitus type 1

80%
Varechova S., Durdik P., Cervenkova V., Ciljakova M., Banovcin P., Hanacek J.
Journal of Physiology and Pharmacology. Supplement
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2007
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tom 58
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nr 5
6
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Helicobacter pylori infection and gastric motor dysfunction

70%
Wingate D. L.
Journal of Physiology and Pharmacology
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1996
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tom 47
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nr 1
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