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Outline features for chemical induction of delayed hypersensitivity

100%

de Araujo Caldas L. Q., Hicks R.

Archivum Immunologiae et Therapiae Experimentalis

1989

tom 37

nr 3-4

The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing alpha-D-mannopyranosyl residues

100%

Kocieba M., Zimecki M., Kruzel M., Actor J.

Cellular and Molecular Biology Letters

2002

tom 07

nr 4

Lactoferrin (LF) is an iron-binding glycoprotein present in the cytoplasmic granules of neutrophils and in external secretions of mammals. Although the biological role of human and bovine lactoferrin has been extensively studied, there is still uncertainty as to the nature and function of lactoferrin receptors. We recently determined that methyl-α-D-mannopyranoside given intraperitoneally (i.p.) could suppress the adjuvant activity of LF in the generation of delayed-type hypersensitivity (DTH) to ovalbumin (OVA). We concluded that the lactoferrin effects in DTH are mediated by carbohydrate-recognizing receptors like the mannose receptor (MR). This study indicates that subcutaneous (s.c.) administration of very small doses of the Man-bovine serum albumin (Man-BSA) complex, together with a sensitizing dose of the antigen, gives the same effects as i.p. administration of methyl-α-D-mannopyranoside. The latter is also a blocker of MR, although of a much lower affinity to the receptor than Man-BSA. The blocking of the adjuvant effect of LF by the Man-BSA complex (when given together with the sensitising dose of antigen) suggests that the function of antigen-presenting cells in the skin (presumably immature dendritic cells expressing MR) is inhibited. The results of our study indicate that a receptor with an affinity for mannose is essential for the mediation of adjuvant lactoferrin function in the generation of DTH.

Immune response of cats experimentally infected with Microsporum canis

100%

Wawrzkiewicz K., Ziolkowska G., Sadzikowski Z., Stepien M.

Polish Journal of Veterinary Sciences

2000

tom 03

nr 2

The aim of this study was an assessment of the immune response of cats experimentally infected with M. canis and a determination of the extent of immunity acquired after recovery. Studies were carried out on 24 domestic, short-haired cats, aged 3-4 months. The resistance of the animals was assessed by reinfection, and the degree of immune response. It has been found that after recovery from an experimental infection with M. canis, the cats which remained in an infected environment for 18 weeks showed no clinical mycotic changes, whereas control animals underwent natural infection within 6 weeks and their mycosis had a typical course. Furthermore reinfection with high doses of the fungus and skin scarification failed to break down this acquired immunity. Hypersensitivity of the delayed type, encountered in cats within 3 weeks after the experimental infection, persisted for 8 months of studies. In an analogous period of time cats infected naturally demonstrated an evidently weaker response determined by the skin test. Positive results of the migration inhibition test were obtained in the period of 3-6 weeks after infection, which corresponded with the period of the persistence of the clinical mycotic changes.

Ograniczanie wyników

1 Archivum Immunologiae et Therapiae Experimentalis

1 Cellular and Molecular Biology Letters

1 Polish Journal of Veterinary Sciences

1 Actor J.

1 Hicks R.

1 Kocieba M.

1 Kruzel M.

1 Sadzikowski Z.

1 Stepien M.

1 Wawrzkiewicz K.

1 Zimecki M.

1 Ziolkowska G.

1 de Araujo Caldas L. Q.

1 2002

1 2000

1 1989

Wyniki wyszukiwania

Outline features for chemical induction of delayed hypersensitivity

The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing alpha-D-mannopyranosyl residues

Immune response of cats experimentally infected with Microsporum canis