Wyniki wyszukiwania

1

Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease

100%

Wesoly J., Sikorski K., Lee C.-K., Bluyssen A. R.

Acta Biochimica Polonica

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2010

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tom 57

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nr 3

The prevalence of cardiovascular disease in patients with renal failure is extremely high and accounts for a large part of the morbidity and mortality. Inflammation participates importantly in host defense against infectious agents and injury, but also contributes to the pathophysiology of many diseases, including cardiovascular atherosclerosis, which is a main problem in patients with renal failure. Recruitment of blood leukocytes to the injured vascular endothelium characterizes the initiation and progression of atherosclerosis and involves many inflammatory mediators, modulated by cells of both innate and adaptive immunity. Excessive inflammatory and immune responses, communicated by these different cell types, are driven by inflammatory cytokines that promote associated tissue damage if cytokine signaling pathways remain unregulated. Thus, pathways capable of suppressing proinflammatory cytokine signaling hold the potential to limit life-threatening cardiovascular events caused by atherogenesis. Suppressor of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. Accumulating evidence supports the idea that dysregulation of cytokine signaling by differential SOCS expression is involved in the pathogenesis of various inflammatory, and immunological diseases, including atherosclerosis. Based on recent observations, in which SOCS expression levels are profoundly altered in kidney disease, we discuss the possibilities of SOCS as new intracellular markers of inflammation as well as their potential atherogenic properties in renal failure related cardiovascular disease.

2

Cytokine signalling-transcription factor cross-talk in T cell activation and Th1-Th2 differentiation

100%

Liberman A. C., Refojo D., Arzt E.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 6

3

Expression of leptin receptor and suppressor of cytokine signaling-3 genes in adenohypophysis of normal-fed and fasted cows

84%

Amstalden M., Spencer T. E., Harms P. G., Williams G. L.

Reproductive Biology

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2005

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tom 05

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nr 2

4

Targeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases

84%

Cetkovic-Cvrlje M., Uckun F. M.

Archivum Immunologiae et Therapiae Experimentalis

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2004

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tom 52

|

nr 2

5

Suppressors of cytokine signalling proteins in innate and adaptive immune responses

84%

Dalpke A., Heeg K.

Archivum Immunologiae et Therapiae Experimentalis

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2003

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tom 51

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nr 2

6

SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children

67%

Ostalska-Nowicka D., Smiech M., Jaroniec M., Zaorska K., Zawierucha P., Szaflarski W., Malinska A., Nowicki M.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 4

7

The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma

67%

Starska K., Forma E., Lewy-Trenda I., Stasikowska O., Brys M., Krajewska W. M., Lukomski M.

Folia Histochemica et Cytobiologica

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2009

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tom 47

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nr 3

8

Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes

67%

Luczynski W., Wawrusiewicz-Kurylonek N., Stasiak-Barmuta A., Urban R., Ilendo E., Urban M., Hryszko M., Kretowski A., Gorska M.

Acta Biochimica Polonica

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2009

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tom 56

|

nr 2

361-370

Diabetes mellitus is one of the most common chronic diseases in children. T regulatory cells (Tregs) modulate response to autoantigens and probably play a role in pathogenesis of type 1 diabetes (T1DM). The aim of the present study was the assessment of T regulatory cells including their percentages and expression of critical genes in these cells in children with newly diagnosed type 1 diabetes. The examined group consisted of 50 children with T1DM. A flow cytometric analysis of T-cell subpopulations was performed using the following markers: anti-CD4, anti-CD25 and anti-CD127 (=IL-7R). Additionally, T regulatory cells were isolated for assessment of mRNA levels for chosen genes with the real-time RT-PCR technique. The percentages of CD4+CD25highCD127dim/- were very low and did not differ between T1DM and control children. We did not observe any statistically significant differences between healthy and diabetic children in mRNA expression for FoxP3, IL-7R (CD127), IL-8RA, IL-10RA, IL-12A, IL-2RA (CD25), IL-21, STAT1, STAT3, SOCS2, SOCS3, TGF-β1-R1, TGF-β-R2 and TBX-21 genes. Interestingly the mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in Treg cells of children with diabetes compared to the control patients. No disturbances in the percentages of T regulatory cells in patients with diabetes but diminished expression of some elements important in Treg function could be the result of an immunologic imbalance accompanying the onset of the diabetes. The results of our study should be used in future research in the field of immunotherapy in pediatric diabetes.

9

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis

67%

Velazquez L.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

|

nr 6

10

Crossroads of cytokine signalling - the chase to stop muscle cachexia

59%

Pajak B., Orzechowska S., Pijet B., Pijet M., Pogorzelska A., Gajkowska B., Orzechowski A.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 9

251-264

Ograniczanie wyników

Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease

Cytokine signalling-transcription factor cross-talk in T cell activation and Th1-Th2 differentiation

Expression of leptin receptor and suppressor of cytokine signaling-3 genes in adenohypophysis of normal-fed and fasted cows

Targeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases

Suppressors of cytokine signalling proteins in innate and adaptive immune responses

SOCS3 and SOCS5 mRNA expressions may predict initial steroid response in nephrotic syndrome children

The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma

Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis

Crossroads of cytokine signalling - the chase to stop muscle cachexia