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Thromboxane increase in irradiated animals is caused by stimulation of cyclooxygenase activity

100%

Sochanowicz B., Dancewicz A. M.

Acta Biochimica Polonica

1992

tom 39

nr 3

The irradiation of whole body of rabbits with a dose <»l' 6.0 Gy causes an increase in thromboxane synthesis from exogenous arachidonic acid. The uptake of |l4C]arachidonic acid and the total amount of radioac- tivity released during collagen stimulated aggregation of platelets are not changed following the exposure of animals. The irradiation changes the relation between released arachidonic acid and synthesized thromboxane. 1'he amount of 12-hydroxyeicosatetraenoic acid remains unchanged. The results indicate that the increase in thromboxane synthesis is not associated with the activation of phospholipase but is caused by stimulation of cyclooxygenase activity.

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Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs

51%

Patrignani P., Panara M. R., Sciulli M. G., Santini G., Renda G., Patrono C.

Journal of Physiology and Pharmacology

1997

tom 48

nr 4

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 Dancewicz A. M.

1 Panara M. R.

1 Patrignani P.

1 Patrono C.

1 Renda G.

1 Santini G.

1 Sciulli M. G.

1 Sochanowicz B.

1 1997

1 1992

Wyniki wyszukiwania

Thromboxane increase in irradiated animals is caused by stimulation of cyclooxygenase activity

Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs