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Helicobacter pylori infection in coronary artery disease

100%

Kowalski M., Pawlik M., Konturek J. W., Konturek S. J.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 3

101-111

The role of inflammation in the pathogenesis and progression of coronary artery disease (CAD) has been increasingly discussed, but still remains unclear. Inflammatory changes in the vessel wall play an important role in the pathogenesis of atherosclerosis. Systemic inflammatory reaction can be detected by showing increased plasma levels of different proinflammatory cytokines and acute-phase proteins. Infectious agents have been linked to coronary heart disease on epidemiological and pathogenetic grounds. The prevalent condition and the exact mechanism of initiation of atherosclerotic vascular disease remain unclear. Nevertheless, many similarities exist between the processes of inflammation and atherogenesis, and the evidence is growing for the role of an active inflammation in the atherosclerosis in the coronary circulation and elsewhere. Although the seroepidemiological and eradication studies have suggested a causal relationship between Helicobacter pylori (Hp) infection and coronary heart disease; the issue is still controversial. The detection of Hp specific DNA in atheromatous plaque material from coronary arteries, but more important, the reduction in restenosis of coronary vessels after Hp eradication could be interpreted as an evidence for the involvement of a Hp infection in the progression of CAD induced by a local inflammatory process.

Evaluation of radial artery as used for coronary vessel grafting in human heart

100%

Jedrzejczyk T., Mikusek J., Rudnicki P., Lopata P.

Folia Morphologica

1996

tom 55

nr 4

A poly[ADP-ribose] synthetase inhibitor, benzamide protects smooth muscle cells but not endothelium against ischemia-reperfusion injury in isolated guinea-pig heart

80%

Jakubowski A., Lomnicka M.

Acta Biochimica Polonica

2007

tom 54

nr 1

Activation of the nuclear enzyme poly(ADP-ribose) synthethase (PARS) is important in the cellular response to oxidative stress. During ischemia and reperfusion (I/R) increased free radical production leads to DNA breakage that stimulates PARS which in turn results in an energy-consuming metabolic cycle and initiation of the apoptotic process. Previous studies have reported that PARS inhibition confers protection in various models of I/R-induced cardiovascular damage. The purpose of this study was to determine the role of PARS inhibition in I/R-induced injury of smooth muscle cells and endothelium in the coronary circulation of the isolated guinea-pig heart. Control hearts and those treated with a PARS inhibitor — benzamide (100 µmol L-1), were subjected to 30 min of subglobal ischemia and subsequent reperfusion (90 min). To analyze the functional integrity of smooth muscle cells and endothelium, one-minute intracoronary infusions of endothelium-independent (sodium nitroprusside, NaNP; 3 µmol L-1) and endothelium-dependent (substance P, SP; 10 nmol L-1) vasodilators were used before ischemia and at the reperfusion time. The degree of the injury of coronary smooth muscle and endothelial cells induced by I/R was estimated in terms of diminished vasodilator responses to NaNP (at 55 min and 85 min of reperfusion) and to SP (at 70 min of reperfusion), respectively, and expressed as the percentage of preischemic response. I/R reduced vasorelaxant responses to both vasodilators by half (to 54.1 ± 5.1% and to 53.6 ± 4.9% of preischemic value for NaNP at 55 min and 85 min of reperfusion, respectively and to 45.9 ± 6.5% for SP at 70 min of reperfusion). PARS inhibition provided complete restoration of vasorelaxation induced by NaNP (107.6 ± 13.3% and 104 ± 14.4% of preischemic response at the two time points of reperfusion, respectively). However, there was no effect on the SP-induced response (48+12.1% of preischemic response). We conclude that pharmacological PARS inhibition with benzamide protects coronary smooth muscle cells but not endothelium against I/R-induced reperfusion injury in the coronary circulation of the guinea-pig heart.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Folia Morphologica

1 Journal of Physiology and Pharmacology. Supplement

1 Jakubowski A.

1 Jedrzejczyk T.

1 Konturek J. W.

1 Konturek S. J.

1 Kowalski M.

1 Lomnicka M.

1 Lopata P.

1 Mikusek J.

1 Pawlik M.

1 Rudnicki P.

1 2007

1 2006

1 1996

Wyniki wyszukiwania

Helicobacter pylori infection in coronary artery disease

Evaluation of radial artery as used for coronary vessel grafting in human heart

A poly[ADP-ribose] synthetase inhibitor, benzamide protects smooth muscle cells but not endothelium against ischemia-reperfusion injury in isolated guinea-pig heart