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NO-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT 1A-receptors

100%

Chlopicki S., Kozlovski V. I., Gryglewski R. J.

Journal of Physiology and Pharmacology

2002

tom 53

nr 4,1

Nebivolol is a unique ß1-adrenoceptor antagonist which possesses peripheral vasodilator properties dependent on endothelial NO. Nebivolol-induced release of NO was attributed to its L stereoisomer and to its ability to stimulate endothelial ß2, ß3 adrenoceptors or 5-HT1A receptors. Here, in the isolated guinea pig heart we analysed coronary vasodilator potency of L- and D-nebivolol and a possible role of ß2, ß3 adrenoceptors and 5-HT1A receptors in nebivolol-induced vasodilation. Surprisingly, we found that not only L-nebivolol (3-30x10-6 M) but also D-nebivolol (3-30x10-6 M) induced coronary vasodilation, and both responses were inhibited by L-NAME (10-4 M). In contrast with the stereoisomers of nebivolol, atenolol at the equimolar concentrations did induce slight vasoconstriction. The nonselective ß1/ß2- adrenoceptor antagonist - nadolol (10-5 M), the selective ß3-adrenoceptor antagonist - L 748337 (10-6 M) and the 5 HT1A receptor antagonist - NAN 190 (5 x 10-6 M), none of them inhibited coronary vasodilation induced by D- and L-nebivolol. In summary, in the isolated guinea pig heart both D- and L-nebivolol act as coronary vasodilators. Coronary vasodilation induced by stereoisomers of nebivolol is mediated by endothelium-derived NO and does not depend on ß2, ß3 adrenoceptors or 5 HT1A receptors.

Eicosanoid profiling in effluent of isolated perfused heart of Tgαq*44 mice with advanced heart failure

84%

Berkowicz P., Kij A., Walczak M., Chlopicki

Journal of Physiology and Pharmacology

2019

tom 70

nr 1

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Effect of ischemic preconditioning on endothelial dysfunction and granulocyte adhesion in isolated guinea-pig hearts subjected to ischemia-reperfusion

67%

Kurzelewski M., Czarnowska E., Maczewski M., Beresewicz A.

Journal of Physiology and Pharmacology

1999

tom 50

nr 4

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Beresewicz A.

1 Berkowicz P.

1 Chlopicki

1 Chlopicki S.

1 Czarnowska E.

1 Gryglewski R. J.

1 Kij A.

1 Kozlovski V. I.

1 Kurzelewski M.

1 Maczewski M.

1 Walczak M.

1 2019

1 2002

1 1999

Wyniki wyszukiwania

NO-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT 1A-receptors

Eicosanoid profiling in effluent of isolated perfused heart of Tgαq*44 mice with advanced heart failure

Effect of ischemic preconditioning on endothelial dysfunction and granulocyte adhesion in isolated guinea-pig hearts subjected to ischemia-reperfusion