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Effects of chelidonine and ukrain on the activity of serum ALT and AST in rats intoxicated by copper chloride

100%

Jagiello-Wojtowicz E., Izdebska M., Piatkowska-Chmiel I.

Herba Polonica

2002

tom 48

nr 4

In this study we have investigated the effects of 10-day treatment with chelidonine or Ukrain on the activities of aminotransferases (ALT and AST) in the serum of copper-poisoned rats. It was found that the acute copper chloride poisoning significantly enhanced AST and ALT activity in serum of rats in comparison in the control group. 10-day treatment with chelidonine (50.0 and 100.0 mg/kg i.p.) or Ukrain (7.0 and 14.0 mg/kg i.p.) significantly increased the activity of AST and ALT (only for Ukrain in a dose of 7.0 mg/kg) in the serum of cooper-poisoned rats in comparison with the group receiving cooper chloride only. The results indicate that 10-day treatment with chelidonine or Ukrain increased the activities of aminotransferases in serum of copper-poisoned rats and did not affect the protective changes.

Ograniczanie wyników

1 Herba Polonica

1 Izdebska M.

1 Jagiello-Wojtowicz E.

1 Piatkowska-Chmiel I.

1 2002

Wyniki wyszukiwania

Effects of chelidonine and ukrain on the activity of serum ALT and AST in rats intoxicated by copper chloride