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Study on convulsive effect of meso-tetra-4N-methylpirydyl-porphyrin [P] in rats

100%

Plech A., Maksym B., Habdas J.

Pestycydy

2004

nr 3-4

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Effect of pizotifen on convulsive effect of meso-tetra-4N-methyl-pirydyl-porphyrin [P] in mice

88%

Maksym B., Habdas J., Plech A.

Pestycydy

2008

nr 1-2

43-49

In this report we present effect of pizotifen, an antagonist of serotonin (5-hydroxytryptamine; 5-HT) receptors, on P-induced convulsions in mice. Experiments were conducted on male mice Balby. Convulsive effect P was determined using the following measures: percentage of mice with seizures, the number of seizure episodes/2 h, the latency time of the beginning P-induced seizure activity in mice and P-induced seizure activity of mice determined by score of Racine. Pretreatment mice with pizotifen (0.5 mg/kg ip) did not prevent convulsive effect P, applied ip at the dose of 50 μmol/kg ip (59.3 mg/kg) but significantly shortened the latency time of the beginning of P-induced seizure activity of mice. We conclude that central serotonin receptors are involved in the mechanism of P-induced convulsions.

Central beta-adrenergic receptors are involved in the mechanism of porphyrin-induced convulsive effect in mice

63%

Maksym B., Habdas J., Plech A.

Pestycydy

2005

nr 4

55-63

Ograniczanie wyników

3 Pestycydy

3 Habdas J.

3 Maksym B.

3 Plech A.

1 2008

1 2005

1 2004

Wyniki wyszukiwania

Study on convulsive effect of meso-tetra-4N-methylpirydyl-porphyrin [P] in rats

Effect of pizotifen on convulsive effect of meso-tetra-4N-methyl-pirydyl-porphyrin [P] in mice

Central beta-adrenergic receptors are involved in the mechanism of porphyrin-induced convulsive effect in mice