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To predict human Biomarker for the obesity using mouse homologous expression data at different theiler stages

100%

Kumar A., Puri R., Gupta K., Pal A.

International Letters of Natural Sciences

2015

tom 45

There are numerous genetic factors like MC4R (Melanocortin-4 receptor), POMC (Proopiomelanocortin), SIM1 (Single Minded Gene) etc. important in obesity, which can be used as biomarker. But more reliable diagnostic markers are the need for today, along with new therapeutic strategies that target specific molecules in the disease pathways. As in mouse and human genes, where mutations in one or both species are associated with some phenotypic characteristics as observed in human disease. In molecular mechanisms of development, differentiation, and disease gene expression data provide crucial insights. Up-regulation and down-regulation of selective genes can have major effects on diet-induced obesity, but there is little or no effect when animals are fed a low-fat diet. In present study we have studied the gene expression data of mouse at different theiler stages using GXD BioMart. The interacting partners and pathway of the genes that are already used as biomarker in mouse as well as in humans have been studied. A gene NPY1R (Neuropeptide Y1 receptor) was taken as common after STRING and KEGG results on the basis of biochemical pathways and interactions similar to MC4R. Our present work focuses on comparative genomics and proteomics analysis of NPY1R, which has led to identification of biomarker by comparing it with already known MC4R human and mouse biomarker. It has been concluded that both the proteins are structurally and functionally similar.

Helicosporidia: a genomic snapshot of an early transition to parasitism

84%

Sun Y., Pombert J.-F.

Acta Societatis Botanicorum Poloniae

2014

tom 83

nr 4

Helicosporidia are gut parasites of invertebrates. These achlorophyllous, non-photosynthetic green algae are the first reported to infect insects. Helicosporidia are members of the green algal class Trebouxiophyceae and are further related to the photosynthetic and non-photosynthetic genera Auxenochlorella and Prototheca, respectively, the latter of which can also turn to parasitism under opportunistic conditions. Molecular analyses suggest that Helicosporidia diverged from other photosynthetic trebouxiophytes less than 200 million years ago and that its adaptation to parasitism is therefore recent. In this minireview, we summarize the current knowledge of helicosporidian genomics. Unlike many well-known parasitic lineages, the Helicosporidium sp. organelle and nuclear genomes have lost surprisingly little in terms of coding content aside from photosynthesis-related genes. While the small size of its nuclear genome compared to other sequenced trebouxiophycean representatives suggests that Helicosporidium is going through a streamlining process, this scenario cannot be ascertained at this stage. Genome expansions and contractions have occurred independently multiple times in the green algae, and the small size of the Helicosporidium genome may reflect a lack of expansion from a lean ancestor state rather than a tendency towards reduction.

Ograniczanie wyników

1 Acta Societatis Botanicorum Poloniae

1 International Letters of Natural Sciences

1 Gupta K.

1 Kumar A.

1 Pal A.

1 Pombert J.-F.

1 Puri R.

1 Sun Y.

1 2015

1 2014

Wyniki wyszukiwania

To predict human Biomarker for the obesity using mouse homologous expression data at different theiler stages

Helicosporidia: a genomic snapshot of an early transition to parasitism