Wyniki wyszukiwania

1

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Reactive modifications of the autonomous time structure in the human organism

100%

Hildebrandt G.

Journal of Physiology and Pharmacology

|

1991

|

tom 42

|

nr 1

The spectrum of biological rhythms exhibits characteristic principles of biological time structure which also rule the functional behaviour. With increasing period lengths the rhythms become increasingly complex. In the long-wave section the rhythmic functions find their corresponding cycles in the environment, whereas the shorter waves respresent only endogenous autonomous rhythms, which maintain an internal time order by means of frequency- and phase-coordination. Under resting conditions and in a state of complete adaptation only a few spontaneous rhythms dominate in the spectrum. However, under loading conditions as well as in pathological situations further periodicities come up. The spectrum of rhythms can be divided into certain blocks, with the period lenghts predominating in each of these whole number frequency ratios forming a harmonic system. Frequency- and phase coordination establish a system of co-action which favours the functional economy of the organism. A tripartite organization of the autonomous rhythms involves different functional behaviours with regard to frequency, amplitude, and phase. Slower rhythms act upon the faster rhythms preferably by modulating their frequencies, while changes of the faster rhythms influence the slower ones by enhancing their amplitudes, multiplying their period lengths and shifting their phases. In principle the reactions of living systems are periodically structured. Reactive periodicity brings to appearance an endogenous time structure, which prefers whole number relationships with the spontaneous rhythms. The phase position of reactive periods depends on the stimulus. The amplitudes dampen down with increasing compensation. From the medical point of view so-called circaseptan (about 7 days) reactive periods are of predominant interest. This periodicity can be observed in numerous adaptive and compensating processes. It does not depend on the external week cycle and was already known to the antiquity.

2

The value of interdisciplinary research: lessons from the 2017 Nobel Prize in chronobiology

72%

Giebultowicz J. M.

Medical Science Pulse

|

2018

|

tom 12

|

nr 1

Since 1901, the Nobel Prize has been awarded to scientists who have made the most important discoveries for the benefit of humanity. The 2017 Nobel Prize in Physiology or Medicine was awarded jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” It may be surprising to learn that those three scientists dedicated their entire careers to research on the fruit fly, Drosophila melanogaster. However, as their studies progressed, it became increasingly clear that the mechanism of the biological clock that they discovered in Drosophila is very similar to a timekeeping mechanism present in mammals, including humans. Through interdisciplinary work between scientists performing basic research on model organisms and doctors working in medical schools, we have learned over time that daily rhythms support human health while disruption of these rhythms is associated with a range of pathological disorders such as cardiovascular problems, metabolic, neurological, and many other diseases. This short review will highlight critical milestones on the way to understanding biological clocks, focusing on the roles played by the three Nobel Prize winners.

3

Slow oscillation circuit of the intergeniculate leaflet

72%

Lewandowski M. H., Blasiak T.

Acta Neurobiologiae Experimentalis

|

2004

|

tom 64

|

nr 2

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Medical Science Pulse

1 Blasiak T.

1 Giebultowicz J. M.

1 Hildebrandt G.

1 Lewandowski M. H.

1 2018

1 2004

1 1991

Reactive modifications of the autonomous time structure in the human organism

The value of interdisciplinary research: lessons from the 2017 Nobel Prize in chronobiology

Slow oscillation circuit of the intergeniculate leaflet