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1

Kainic acid induces expression of caveolin-1 in activated microglia in rat brain

100%
Takeuchi S., Matsuda W., Tooyama I., Yasuhara O.
Folia Histochemica et Cytobiologica
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2013
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tom 51
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nr 1
2
Content available remote

The implication of adipocyte ATP-binding cassette A1 and G1 transporters in metabolic complications of obesity

100%
Choromanska B., Mysliwiec P., Hady H. R., Dadan J., Mysliwiec H., Bonda T., Chabowski A., Miklosz A.
Journal of Physiology and Pharmacology
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2019
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tom 70
|
nr 1
3

Small high density lipoprotein subclasses: some of their physico-chemical properties and stability in solution

100%
Atmeh R. F., Issa A. E. O.
Acta Biochimica Polonica
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2005
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tom 52
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nr 2
Small high density lipoproteins (SHDL) contribute to the protection from atherosclerosis, but detailed information about their properties is not available yet. We isolated four of the smallest HDL subclasses that contain apoA-I alone, the small lipoprotein A-I (SLpAI), by their separation on gradient polyacrylamide gel followed by electroelution. Their physico-chemical properties were calculated from their displacement in non-denaturing gradient polyacrylamide gel under the effect of electrical potential. The properties are: Stokes’ radii 2.96–3.56 nm; molecular masses 42–70 kDa; net negative charge 7.2–13.5; surface charge densities 3139–4069 –esu ∙ cm–2; surface potentials 10.6–15.7 –mV; coefficients of friction 5.74­–6.90 × 10–8 g ∙ s–1; and diffusion coefficients 5.76–6.94 × 10–7 cm2 ∙ s–1. We found that these particles were of low stability as they underwent molecular transformation into larger particles on storage. The estimated dimensions of these particles do not support ellipsoidal shape, therefore, the most probable shape is spherical; consequently, their hydrated characteristics were estimated. We conclude that these particles have high values of negative surface charge and diffusion coefficients, and are of low stability. Their small Stokes’ radii were similar to each other and they are spherical and highly hydrated.
4

The origin and metabolism of a nascent pre-beta high density lipoprotein involved in cellular cholesterol efflux

80%
Wroblewska M.
Acta Biochimica Polonica
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2011
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tom 58
|
nr 3
 The pre-β HDL fraction constitutes a heterogeneous population of discoid nascent HDL particles. They transport from 1 to 25 % of total human plasma apo A-I. Pre-β HDL particles are generated de novo by interaction between ABCA1 transporters and monomolecular lipid-free apo A-I. Most probably, the binding of apo A-I to ABCA1 initiates the generation of the phospholipid-apo A-I complex which induces free cholesterol efflux. The lipid-poor nascent pre-β HDL particle associates with more lipids through exposure to the ABCG1 transporter and apo M. The maturation of pre-β HDL into the spherical α-HDL containing apo A-I is mediated by LCAT, which esterifies free cholesterol and thereby forms a hydrophobic core of the lipoprotein particle. LCAT is also a key factor in promoting the formation of the HDL particle containing apo A-I and apo A-II by fusion of the spherical α-HDL containing apo A-I and the nascent discoid HDL containing apo A-II. The plasma remodelling of mature HDL particles by lipid transfer proteins and hepatic lipase causes the dissociation of lipid-free/lipid-poor apo A-I, which can either interact with ABCA1 transporters and be incorporated back into pre-existing HDL particles, or eventually be catabolized in the kidney. The formation of pre-β HDL and the cycling of apo A-I between the pre-β and α-HDL particles are thought to be crucial mechanisms of reverse cholesterol transport and the expression of ABCA1 in macrophages may play a main role in the protection against atherosclerosis.
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