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Z wyciągu heksanowego, chloroformowego i metanolowego z korzeni Janakia arayalpatra wyizolowano 8 związków. Związki te zostały określone jako octan a-amyryny, aldehyd 4-meto- ksy-salicylowy, aldehyd 3-hydroksy-anyżowy, magnifikol (12,20(29)-lupadien-3-ol), ß-sitoste- rol, naryngenina, kemferol, aromadendryna.
The chloroform extract of Ailanthus altissima stem bark and the alcoholic extract of Ziziphus spina christi roots were tested for their antischistosomal and hepatoprotective effects. The effect of schistosomal infection and treatment with both extracts on the activities of aspartate and alanine aminotransferases, acid phosphatase, 5’nucleotidase, glucose-6-phosphatase, lactate dehydrogenase, alkaline phosphatase and succinate dehydrogenase were estimated as measures of hepatic metabolic function, on free radical production in the form of lipid peroxides and on the levels of certain antioxidants namely, catalase, glutathione, vitamins C and E. In addition, the efficiency of the tested extracts on reducing the worm burden and ova counts in the infected mice was evaluated. The obtained data revealed that infection with S.mansoni increased lipid peroxides and decreased all antioxidant levels. On the other hand, the activities of acid phosphatase and 5`nucleotidase were higher while those of glucose-6-phosphatase, lactate dehydrogenase, alkaline phosphatase and succinate dehydrogenase were lower with respect to control. However, treatment with both A.altissima and Z.spina christi ameliorated the disturbed lipid peroxides, antioxidants and enzymes’ levels to nearly the control values, the chloroform extract of A.altissima showing a more pronounced improving effect against liver damage caused by parasitic infection. This study confirms the recent approach of many researchers for the use of plants in the treatment of liver diseases as alternatives to the classical chemotherapeutic drugs which may provide a low incidence of side effects.
Preliminary phytochemical screening of various extracts of Amoora ruhituka bark were investigated which reveals the presence of several secondary metabolites in each extracts. The antibacterial activity of all the extracts was tested against four gram negative bacterial strains. The results indicated the zone of inhibition which ranges from 11.30±577 to 18.7±0.577 for different extracts in which Methanol extract has shown highest zone of inhibition for Salmonella typhimurium followed by Enterobacter aerogenes , E coli and P aeruginosa whereas benzene extract has showed the least zone of inhibition and the minimum inhibitory concentration (MIC) of the different extracts ranging from 0.78 mg/ml to 6.25mg/ml.The complete results of this study provides a essential data for the use of Amoora ruhituka for the treatment of infection associated diseases.
The antimicrobial activity of chloroform and methanol extracts of Lennea coromandelica were screened for their was studied against gram positive bacteria strains Staphylococcus aureus, Streptococcus pyogenes and Bacillus subtilis gram negative bacteria strains Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli and fungal strains such as Candida albicans, C. parapsilosis, C. krusei and C. glabrata using disc diffusion method, determination of Minimum Inhibitory Concentrations (MIC), Minimum Bacterial Concentrations (MBC) and Minimum Fungicidal Concentrations (MFC). The antimicrobial activity for different concentrations like 250 μg, 500 μg and 1000 μg of different solvent extracts of Lannea cormandelica. bacterial strains and recorded in highest mean zones of inhibition ranged from 19.6 mm and Candidal strains and the exhibited the highest mean zones of inhibition ranged from 10.6 mm. Methanol extracts showed the best results as inhibition zones against tested organisms. Results showed also that, the greatest effect was towards Staphylococcus aureus and the lowest was against Candida krusei. The present study reported the great effect of Lannea cormandelica extracts against some of most important pathogens.
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