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1

Effects of chelidonine on some biochemical parameters in the serum of rats subacutely intoxicated by copper

100%
Jagiello-Wojtowicz E., Piatkowska-Chmiel I.
Herba Polonica
|
2004
|
tom 50
|
nr 3-4
The study was investigated the effects of 10-day treatment with chelidonine (50 and 100 mg/kg ip) on the concentration of creatinine and urea in the blood serum of rats subacutely intoxicated by copper. Subacute intoxication with copper chloride has been found to cause a significant decrease in the urea level and no effect 011 the creatinine level. Chelidonine had virtually 110 effect on the parameters examined except for the decrease in urea in the dose of 50 mg/kg as compared with the control group. 10-day treatment with both doses of chelidonine significantly decreased the level of creatinine and increased the level of urea (dose 100mg/kg) in the serum of intoxicated rats.
2

Effects of chelidonine and ukrain on the activity of serum ALT and AST in rats intoxicated by copper chloride

84%
Jagiello-Wojtowicz E., Izdebska M., Piatkowska-Chmiel I.
Herba Polonica
|
2002
|
tom 48
|
nr 4
In this study we have investigated the effects of 10-day treatment with chelidonine or Ukrain on the activities of aminotransferases (ALT and AST) in the serum of copper-poisoned rats. It was found that the acute copper chloride poisoning significantly enhanced AST and ALT activity in serum of rats in comparison in the control group. 10-day treatment with chelidonine (50.0 and 100.0 mg/kg i.p.) or Ukrain (7.0 and 14.0 mg/kg i.p.) significantly increased the activity of AST and ALT (only for Ukrain in a dose of 7.0 mg/kg) in the serum of cooper-poisoned rats in comparison with the group receiving cooper chloride only. The results indicate that 10-day treatment with chelidonine or Ukrain increased the activities of aminotransferases in serum of copper-poisoned rats and did not affect the protective changes.
3

The influence of chelidonine and Ukrain on the beta-2-microglobulin concentration in the serum of lead-poisoned rats

84%
Jagiello-Wojtowicz E., Maciejewska-Kozak H., Chodkowska A., Radej R.
Herba Polonica
|
2003
|
tom 49
|
nr 3-4
The present study investigated the effects of single (lx) administration and a 10-day treatment with chelidonine (50 and 100 mg/kg i.p.) or drug Ukrain (7 and 14 mg/kg i.p.) on the ß2-microglobulin concentration in the serum of acute or subacute lead-poisoned rats (30 mg/kg i.p.). Both acute and subacute lead-intoxication significantly enhanced ß2- microglobulin concentration in the rats serum in comparison to the control groups. In acute poisoning only chelidonine (100 mg/kg i.p.) significantly decreased ß2-microgIo- bulin concentration in the rat serum. In subacute lead intoxication, 10-day treatment with chelidonine (50 mg/kg i.p.) or Ukrain (14 mg/kg i.p.) significantly decreased ß2- microglobulin in the serum of rats. Both chelidonine as well as Ukrain decreased nefrotoxicity induced by lead acetate. These investigations are to be continued.
4

Effects of chelidonine and ukrain on the activity of aminotransferases in the serum of rats intoxicated by tin chloride

67%
Jagiello-Wojtowicz E., Piatkowska-Chmiel I., Chodkowska A., Izdebska M.
Herba Polonica
|
2002
|
tom 48
|
nr 4
The aim of the presented paper was to investigate the effects of chelidonine or Ukrain on the activity of serum aminotransferases AST and ALT in serum of tin-poisoned rats. The acute administration of tin chloride significantly increased AST and ALT activity in serum of rats in comparison in the control group. 10-day treatment with chelidonine (only in a dose of 100.0 mg/kg i.p.) significantly enhanced the activity of AST and did not affect the activity of ALT in the serum of tin-poisoned rats in comparison with the group receiving tin chloride only. However, 10-day treatment with Ukrain in doses of 7.0 and 14.0 mg/kg i.p. decreased the activity of ALT and increased the activity of AST (only in a dose of 14.0 mg/kg i.p.) in the serum of tin-poisoned rats.
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