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  1. 5 Folia Histochemica et Cytobiologica

  2. 2 Acta Biochimica Polonica

  3. 2 Bulletin of the Veterinary Institute in Puławy

  4. 1 Animal Science Papers and Reports

  5. 1 Archivum Immunologiae et Therapiae Experimentalis

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  1. 4 Gozdzicka-Jozefiak A.

  2. 3 Szostek S.

  3. 2 Klimek M.

  4. 2 Kosz-Vnenchak M.

  5. 2 Kwasniewska A.

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  1. 1 2019

  2. 2 2017

  3. 1 2015

  4. 3 2012

  5. 1 2011

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1

Physical state of human papillomavirus type 16 in cervical cell DNA

100%
Szostek S., Klimek M., Zawilinska B., Kosz-Vnenchak M.
Folia Biologica
|
2008
|
tom 56
|
nr 3-4
269-271
2

Small cell carcinoma of the uterine cervix - an uncommon variant of cervical cancer with neuroendocrine features

100%
Lenczewski A., Terlikowski S., Sulkowska M., Famulski W., Sulkowski S., Kulikowski M.
Folia Histochemica et Cytobiologica. Supplement
|
2001
|
tom 39
|
nr 1
3

Immunohistochemical assay of p53, cyclin D1, c-erbB2, EGFr and Ki-67 proteins in HPV-positive and HPV-negative cervical cancers

100%
Kedzia W., Schmidt M., Frankowski A., Spaczynski M.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 1
4

Inhibition of EGFR nuclear shuttling decreases irradiation resistance in HeLa cells

84%
Wei H., Zhu Z., Lu L.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 2
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3N-azido-3N-deoxythymidine (AZT)

84%
Czajkowska-Wojciechowska E., Singh A., Trznadel R., Ruszkowski P., Celewicz L.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2019
|
tom 100
|
nr 1
6
Content available remote

The lactate receptor (HCAR1/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa cells

84%
Wagner W., Kania K. D., Blauz A., Ciszewski W. M.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 4
7

Comparison of the sensitivity and specificity of real-time PCR and in situ hybridization in HPV16 and 18 detection in archival cervical cancer specimens

84%
Biesaga B., Szostek S., Klimek M., Jakubowicz J., Wysocka J.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 2
8

In vitro anti-cancer properties of natural vs synthetic conjugated linoleic acid

84%
Lipkowski A. W., Walisiewicz-Niedbalska W., Patkowska-Sokola B., Opolski A., Bodkowski R., Wietrzyk J., Pelczynska M., Nasulewicz A., Gwardiak H., Kwiatkowski J.
Animal Science Papers and Reports
|
2003
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tom 21
|
nr 1
Anti-proliferative activity was investigated of C18:2 9cis,11trans (conjugated linoleic acid – CLA) isomer isolated from sheep milk fat. The research was conducted on sheep milk fatty acids in natural composition (FA-1) containing 2.0% of the C18:2 9cis,11trans CLA isomer and preparation enriched with CLA, containing up to 9.2% of the CLA isomer (FA-2). The process of enrichment of FA-1 was carried out in two steps. Step I was to remove mid-chain-length saturated fatty acids, primarily C16,by forming adducts with urea (to obtain FA-U), while in step II the short-chain acids were removed by way of supercritical extraction with CO2. The final preparation obtained (FA-2) contained 9.2% of the C18:2 9cis,11trans isomer. A natural sheep milk fatty acid composition (FA-1), the CLA-enriched product (FA-2) and a commercial CLA preparation (CP) were tested for anti-proliferative activity against the cells of human cervical carcinoma (KB), and leukaemia (HL-60). The ID50 dose (resulting in a 50% inhibition of cell proliferation) of FA-2 was found lower than that of the CP preparation. The SRB test showed.
9

The effect of brachytherapy on antioxidant status and lipid peroxidation in patients with cancer of the uterine cervix

84%
Mila-Kierzenkowska C., Kedziora-Kornatowska K., Wozniak A., Drewa T., Wozniak B., Drewa S., Krzyzanska-Malinowska E., Makarewicz R.
Cellular and Molecular Biology Letters
|
2004
|
tom 09
|
nr 3
The aim of this study was to investigate the effect of brachytherapy on lipid peroxidation and antioxidant status in patients with uterine cervix cancer. The study was conducted on 84 uterine cervix cancer patients from the Brachytherapy Department of the Regional Centre of Oncology in Bydgoszcz. Patients with uterine cervix cancer were found to have elevated levels of lipid peroxidation and antioxidant defence system impairment relative to healthy females. The results of the study indicate that brachytherapy has no direct effect on the antioxidant system of patients with uterine cervical carcinoma. However, the normalisation of catalase and glutathione peroxidase activity and erythrocyte TBARS level observed six months after the end of therapy may be due to the arrest of the progression of the disease.
10

Prevalence of Chlamydia trachomatis in cervical and vulvar carcinoma of the Lublin Region patients

84%
Kwasniewska A., Skoczynski M., Korobowicz E., Semczuk M., Gozdzicka-Jozefiak A.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 3
The aim of the study was to evaluate frequency of occurrence of Chlamydia trachomatis infection in samples of cervical and vulvar cancer in patients of the Lublin Region. The study was performed on paraffin sections prepared from the specimens of cervical cancer obtained from 570 patients and of vulvar cancer from 46 patients. We identified archival diagnostic phase tissue specimens. The control material to that obtained from patients with cervical cancer consisted of normal cervical tissues. The control material to that obtained from patients with vulvar cancer were fragments of normal epithelial tissue collected from the same paraffin blocks containing material from the margin of surgical section during vulvectomy. In order to identify Chlamydia trachomatis, DNA isolated from archival material was analysed and PCR was performed using starters complementary to Chlamydia trachomatis. Statistically significantly higher frequency of the occurrence of Chlamydia trachomatis was observed in sections from patients with invasive cervical cancer compared to control group. In the analysed material, the frequency of cases of vulvar cancer with co-occurrence of Chlamydia trachomatis infection was not statistically significant. Chlamydia trachomatis may not be directly involved in the oncogenic processes but may enhance the possibility of oncogenesis or infect cancer tissues opportunistically.
11

The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome

84%
Schmidt M. T., Olejnik A. K., Gozdzicka-Jozefiak A.
Acta Biochimica Polonica
|
2005
|
tom 52
|
nr 4
Human papillomavirus (HPV) infection is a major risk factor for the development of cervical cancer. The HPV-induced immortalization of epithelial cell usually requires integration of the viral DNA into the host cell genome. The integration event causes disruption of the E2 gene and this is followed by overexpression of the E6 and E7 oncoproteins. The E2 protein is a transcription factor that regulates expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region. We used an in vitro cell culture model to explore the role of the E2 protein in the transcriptional control of the HPV16 long control region. Employing transient and stable transfection experiments we simulated the episomal and integrated states of the viral genome, respectively. We show that the E2 protein up-regulates E6/E7 transcription from episomal DNA but represses it in the case of integrated DNA. The activator function of the E2 protein seems to counteract the repressive chromatin structure formed over episomal DNA. Steroid hormones and retinol also modulate oncogene transcription differently depending on the physical structure of the viral DNA. Our data suggest regulatory mechanisms involving interactions between the E2 protein and nuclear hormone receptors.
12

Immunosuppressive and cytogenetic effects of pelvic irradiation on the peripheral lymphocytes of patients with cervical cancer. One year follow-up

84%
Vuckovic-Dekic L., Spremo B., Stanojevic-Bakic N., Garzicic B., Durbaba M.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
13

Relationships between HPV 16 DNA presence in invasive squamous cell carcinoma of the uterine cervix and their metastases

84%
Slodzinski H., Szepietowska M., Polz-Dacewicz M., Putowski L., Cwierz E.
Bulletin of the Veterinary Institute in Puławy. Supplement
|
2002
14

Overexpression of glycosylated proteins in cervical cancer recognized by the Machaerocereus eruca agglutinin

67%
Solorzano C., Mayoral M. A., Carlos M. A., Berumen J., Guevara J., Chavez F. R., Mendoza-Hernandez G., Agundis C., Zenteno E.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 3
15
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis

67%
Wegierek-Ciuk A., Arabski M., Kedzierawski P., Florek A., Solowiej D., Gozdz S., Lisowska H., Kowalik A., Kowalska M., Wojcik A., Polanska J., Lankoff A.
Journal of Pre-Clinical and Clinical Research
|
2015
|
tom 09
|
nr 2
Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.
16

Pretreatment plasma levels and diagnostic utility of hematopoietic cytokines in cervical cancer or cervical intraepithelial neoplasia patients

67%
Lawicki S., Bedkowska G. E., Gacuta-Szumarska E., Knapp P., Szmitkowski M.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 2
17

Herpesviruses as possible cofactors in HPV-16-related oncogenesis

67%
Szostek S., Zawilinska B., Kopec J., Kosz-Vnenchak M.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 2
337-342
 Cervical carcinogenesis is a complex problem with papillomavirus widely accepted as a causative agent. Integration of a human papillomavirus (HPV) of the high-risk type into the host cell genome is one of the major contributing factors to cervical malignant transformation. In this study, the correlation of CMV, EBV, HSV-1, HSV-2, HHV-6 and HHV-7 infections with the physical status of the HPV genome in cervical cancer and precancerous cervical lesions was investigated in sixty HPV-16-positive women. Cervical secretion samples were submitted to DNA extraction and analyzed by PCR. HPV-16 DNA was confirmed in genotyping with the reverse hybridization line probe assay. Multiplex PCR with specific primers for the E2/E6 genes was used to assess the viral integration status of HPV-16. Our results show that CMV DNA was more frequently present in samples with mixed forms of HPV-16 than in the episomal form (P < 0.025). Such a correlation was also observed in the case of EBV (P < 0.005). The presence of CMV resulted in a six-fold (OR 6.069; 95% CI 1.91-19.22; P = 0.002), while EBV caused a seven-fold (OR 7.11; 95% CI 1.70-29.67; P = 0.007) increase in the risk of the integrated or mixed HPV-16 genome occurrence. Our data suggest that coinfection with herpesviruses, especially CMV and EBV, may be involved in the integration of the HPV-16 genome and may contribute to the development of cervical cancer.
18

Analysis of expression of AIF and PARP-1 in cancerogenesis of HPV-positive cervix

67%
Warowicka A., Kwasniewska A., Sobieraj M., Gozdzicka-Jozefiak A.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 3
The mRNA expression of AIF and PARP-1 in HPV negative non-tumour epithelial cells and HPV-positive cervical cancer cells using the real-time PCR method was examined. An increased level of AIF and PARP-1 mRNA in cervical cancer cells in comparison to normal epithelial cells was demonstrated. These results suggest that changes in the mRNA expression level of AIF and PARP-1 might be involved in cervical cancer development. The analysis of these two factors may represent a new molecular tool for cervical cancer prevention in women with HPV persistent infection.
19

Molecular basis of gynaecological malignancies: viral pathogenesis of cervical cancer

67%
Pirog E. C.
Bulletin of the Polish Academy of Sciences. Biological Sciences
|
1996
|
tom 44
|
nr 1-2
20

The association of human papillomavirus infection with cervical cancer risk in women

67%
Gozdzicka-Jozefiak A., Kedzia W. M., Poreba E., Zimna K., Dziabaszewska E., Kedzia H.
Biological Bulletin of Poznań
|
1996
|
tom 33
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