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Health benefits and risk associated with adopting a vegetarian diet

100%

Pilis W., Stec K., Zych M., Pilis A.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 1

A vegetarian diet may be adopted for various reasons that can include ecological, economic, religious, ethical and health considerations. In the latter case they arise from the desire to lose weight, in tackling obesity, improving physical fitness and/or in reducing the risk of acquiring certain diseases. It has been shown that properly applied vegetarian diet is the most effective way of reducing body mass (expressed as BMI), improving the plasma lipid profile and in decreasing the incidence of high arterial blood pressure, cardiovascular disease, stroke, metabolic syndrome and arteriosclerosis. In addition, improved insulin sensitivity together with lower rates of diabetes and cancer has been observed. Some studies have however found that a vegetarian diet may result in changes adversely affecting the body. These could include; hyperhomocysteinaemia, protein deficiency, anaemia, decreased creatinine content in muscles and menstrual disruption in women who undertake increased physical activity. Some of these changes may decrease the ability for performing activities that require physical effort. Nevertheless, on balance it can be reasonably concluded that the beneficial effects of a vegetarian diet significantly, by far, outweigh the adverse ones. It should also be noted that the term ‘vegetarian diet’ is not always clearly defined in the literature and it may include many dietary variations.

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Inhibition of blood platelet adhesion by phenolics' rich fraction of Hippophae rhamnoides L. fruits

84%

Olas B., Kontek B., Szczesna M., Grabarczyk L., Stochmal A., Zuchowski J.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 2

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Regulation of angiogenesis by hypoxia: the role of microRNA

84%

Madanecki P., Kapoor N., Bebok Z., Ochocka R., Collawn J. F., Bartoszewski R.

Cellular and Molecular Biology Letters

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2013

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tom 18

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nr 1

Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.

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Kaempferol, but not resveratrol inhibits angiotensin converting enzyme

84%

Olszanecki R., Bujak-Gizycka B., Madej J., Suski M., Wolkow P. P., Jawien J., Korbut R.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 2

Inhibition of angiotensin converting enzyme (ACE) has proved to be beneficial in the treatment of various cardiovascular disorders. The aim of this study was to evaluate ACE inhibitory potential of two polyphenolic compounds with different structures: resveratrol (present in high quantities in French wine) and kaempferol (abundant in greens), using method of liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) for ex vivo measurement of angiotensin I to angiotensin II conversion by ACE in aortic tissue of Wistar-Kyoto rats. In this setting, kaempferol (10-30-100 µM), but not resveratrol (10-30-100 µM) appeared to inhibit dose-dependently conversion of Ang I to Ang II. Although the mechanism of ACE inhibition by kaempferol remains to be elucidated, this observation may help in search or designing of new classes of ACE inhibitors.

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Determinants of plasma homocysteine in coal miners

67%

Mungan A. G., Can M., Kiran S., Acikgoz S., Guven B.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Aim: Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Materials and Methods: Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. Results: There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Conclusions: Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.

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Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion

67%

Zbikowska H. M., Olas B.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 3

Ograniczanie wyników

Health benefits and risk associated with adopting a vegetarian diet

Inhibition of blood platelet adhesion by phenolics' rich fraction of Hippophae rhamnoides L. fruits

Regulation of angiogenesis by hypoxia: the role of microRNA

Kaempferol, but not resveratrol inhibits angiotensin converting enzyme

Determinants of plasma homocysteine in coal miners

Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion