Wyniki wyszukiwania

1

Supernormal excitability in the Luo-Rudy I model of the mammalian ventricular cell

100%

Cieniawa J., Gawda H.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

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4-aminopyridine induces positive lusitropic effects and prevents the negative inotropic action of phenylephrine in the rat cardiac tissue subjected to ischaemia

75%

Kocic I., Dworakowska D., Dworakowski R.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 3

3

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

63%

Karbowska J., Kochan Z., Smolenski R. T.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 1

Cardiac hypertrophy in humans is associated with a decrease in myocardial fatty acid β-oxidation (FAO) and accompanying alterations in metabolic gene expression. Flux through the cardiac FAO pathway, which is the principal source of energy production in the adult mammalian heart, is tightly controlled in accordance with energy demands. In rodents, the FAO pathway is under control of a nuclear peroxisome proliferator-activated receptor α (PPARα). We sought to delineate the molecular regulatory events involved in the energy substrate preference switch from fatty acids to glucose during cardiac hypertrophic growth in humans. We analysed the amount of PPARα protein in human cardiac tissue. PPARα protein level was measured in homogenates prepared from left ventricular biopsies taken from five control donor hearts and compared to the amount of this transcription factor in biopsies from five patients with compensated end-stage heart failure (HF) at the time of transplantation. Using Western blot analysis with a monoclonal antibody against human PPARα, we observed a significant decrease (54%) in the mean amount of PPARα in the group of HF patients compared to that in the donor tissue. This study indicates that the decrease in cardiac PPARα transcription factor gene expression observed in the failing human heart could play an important role in a reduction in fatty acid utilisation by the adult heart during cardiac hypertrophy.

4

Modulation by testosterone of an endogenous hERG potassium channel current

51%

Ridley J. M., Shuba Y. M., James A. F., Hancox J. C.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 3

395-407

hERG (human ether-a-go-go-related gene) potassium (K+) channels are expressed in a range of tissue types including neuroblastoma cells and the heart, in which hERG K+ current is important for action potential repolarization. Whilst gender differences in cardiac repolarization and the QT interval of the cardiac electrocardiogram are well-established, comparatively little is known about regulation of hERG channels by sex hormones. In this study, whole-cell patch-clamp recordings were made at 37 °C from SH-SY5Y human neuroblastoma cells to investigate modulation of endogenous hERG K+ channel current (IhERG) by testosterone. Acutely applied testosterone at a physiologically relevant concentration (10 nM) produced a modest (~13-15 %) increase in IhERG amplitude, whilst a high concentration (1 µM) slightly decreased IhERG. The stimulatory effect of testosterone was inhibited by the androgen receptor antagonist flutamide (10 µM) and the PI-3 kinase inhibitor wortmannin (1 µM). Chronic (24 h) application of testosterone also augmented IhERG via flutamide-sensitive receptor activation, without modulation of the current's voltage-dependence. These results demonstrate for the first time that testosterone can stimulate hERG K+ channels via activation of classical androgen receptors and implicate PI-3 kinase in the acute response.

5

ATP-regulated potassium channel

51%

Szewczyk A., Wojtczak L.

Biophysics of Membrane Transport

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1994

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tom 12

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nr 2

6

Effects of grayanotoxin-I on threshold intensity and compound action potential of frog sciatic nerve

51%

Ascioglu M., Ozesmi C.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 2

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

2 Cellular and Molecular Biology Letters

1 Biophysics of Membrane Transport

1 Ascioglu M.

1 Cieniawa J.

1 Dworakowska D.

1 Dworakowski R.

1 Gawda H.

1 Hancox J. C.

1 James A. F.

1 Karbowska J.

1 Kochan Z.

1 Kocic I.

1 Ozesmi C.

1 Ridley J. M.

1 Shuba Y. M.

1 Smolenski R. T.

1 Szewczyk A.

1 Wojtczak L.

1 2008

1 2003

1 2002

1 1999

1 1996

1 1994

Supernormal excitability in the Luo-Rudy I model of the mammalian ventricular cell

4-aminopyridine induces positive lusitropic effects and prevents the negative inotropic action of phenylephrine in the rat cardiac tissue subjected to ischaemia

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

Modulation by testosterone of an endogenous hERG potassium channel current

ATP-regulated potassium channel

Effects of grayanotoxin-I on threshold intensity and compound action potential of frog sciatic nerve