Studies were carried out to elucidate lipid peroxidation and crypt survival in the small intestinal mucosa of mice pretreated per os with either diethylnitrosamine (DENA) (0.01, 0.1, or 1.0 mg kg/b.w) or normal saline daily for 21 days, and whole-body gamma irradiated (2.5, 5.0. 7.5, or 10;0 Gy) following post-DENA and/or post-saline (control) exposures. Results show that DENA lowered the total value of mean lethal radiation dose for crypt cells, and the agent was enable to sensitize intestinal crypts to y-rays. Present data suggest that gamma radiation- and/or DENA-induced lipid peroxidation and/or pro-oxidant shift(s) is a risk factor for murine crypt survival.
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