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Potent antifungal properties of gallic acid in Sarcochlamys pulcherrima against Candida auris

100%

Akhtar N., Pandey D., Mannan A. U., Sarkar A., Sharma H., Kumar M., Ghosh A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2023

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tom 104

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nr 2

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Pharmacological impact on loop gain properties to prevent irregular breathing

100%

Kiwull-Schone H., Teppema L., Wiemann M., Kalhoff H., Kiwull P.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

Theory predicts respiratory instabilities at elevated system loop gain (G), determined by such factors as ventilatory CO2 sensitivity, set-point PCO2, and metabolic rate. In anesthetized rabbits, the effects on G of carbonic anhydrase (CA) inhibitors and of different sodium/proton exchanger type 3 (NHE3) inhibitors were studied. Acetazolamide significantly reduced G by 42.0 ± 9.3% and methazolamide by 35.0 ± 9.5% (each n = 7, P<0.01). Irrespective of the substance, NHE3 inhibition reduced G by 33.0 ± 7.8% (n = 10, P<0.01) at 35.5 ± 1.6 mmHg PaCO2 (mean ±SE), but not at lower arterial CO2 levels (n=5). Since high baseline PCO2 coincides with elevated brainstem NHE3 mRNA expression, this may also account for a higher risk of sleep apnea (or even occurrence of sudden infant death). Therefore, NHE3 inhibitors may gain similar therapeutic importance in the treatment of irregular breathing as CA inhibitors. Generally, effective treatment should aim at a low system loop gain, by reducing respiratory chemosensitivity, improving blood gases and preventing low metabolic rates.

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The toxic Doppelganger: on the ionic and molecular mimicry of cadmium

84%

Chmielowska-Bak J., Izbianska K., Deckert J.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

Cadmium is a toxic heavy metal which can cause numerous alterations in cell functioning. Exposure to cadmium leads to generation of reactive oxygen species, disorders in membrane structure and functioning, inhibition of respiration, disturbances in ion homeostasis, perturbations in cell division, and initiation of apoptosis and necrosis. This heavy metal is considered a carcinogen by the Agency for Toxic Substances and Disease Registry. At least some of the described toxic effects could result from the ability of cadmium to mimic other divalent ions and alert signal transduction networks. This review describes the role of cadmium mimicry in its uptake, reactive oxygen species generation, alterations in calmodulin, Wnt/β-catenin and estrogen signaling pathways, and modulation of neurotransmission. The last section is dedicated to the single known case of a favorable function performed by cadmium mimicry: marine diatoms, which live in zinc deficient conditions, utilize cadmium as a cofactor in carbonic anhydrase - so far the only described cadmium enzyme.

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Comparative analysis of alphaglobin and carbonic anhydrase I cDNAs of the opossum Monodelphis domestica with related vertebrate sequences

84%

Barome P. O.

Folia Biologica

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2003

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tom 51

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nr 1-2

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Carboxylating enzymes and carbonic anhydrase functions were suppressed by zinc deficiency in maize and chickpea plants

67%

Salama Z. A., El-Fouly M. M., Lazova G., Popova L. P.

Acta Physiologiae Plantarum

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2006

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tom 28

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nr 5

Maize and chickpea plants were grown in a controlled environment with 0.5 pM Zn or without Zn and various photosynthetic reactions were studied. The chlorophyll level, the rate of photosynthesis and photosystem II activity, the activity of carboxylating enzymes and that of carbonic anhydrase were suppressed by Zn deficiency in both plant species. Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) was quantified using polyacrylamide gel electrophoresis. Growing plants in a medium without Zn caused a decrease in the total protein level and in the levels of large and small subunits of Rubisco.

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Oszacowanie dystansu genetycznego u owiec na podstawie polimorfizmu transferyn, hemoglobiny i anhydrazy węglanowej

59%

Bojczuk H., Bojczuk B., Zurkowski M.

Zeszyty Problemowe Postępów Nauk Rolniczych

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1988

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tom 352

На основании анализа трех полиформных систем белков ( Hb ,Tf и CA), рассматривая частоту аллелей, коэффициент гомозиготности, коэффициент „чистопородности", коэффициент сродственности и генетическую дистанцию, можно говорить о существенных генетических различиях между сравниваемыми четырьмя популяциями овец: мериносом, низинной овцой и овцой разновидности Желязна.