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1

School based skin cancer education intervention

100%
Reding D. J., Fischer V., Lappe K., Gunderson P. D.
Annals of Agricultural and Environmental Medicine
|
1994
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tom 01
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nr 2
2

Clinical relevance of the inhibitory effect of green tea catechins [GTCs] on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view

100%
Bettuzzi S., Rizzi F., Belloni L.
Polish Journal of Veterinary Sciences
|
2007
|
tom 10
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nr 1
Prostate cancer (CaP) is a fast-growing health and social problem already representing the second leading cause of cancer-related death among men in Western countries. Lifestyle-related factors and diet are major contributors for CaP promotion. Because of unfavourable prognosis of extra-prostatic CaP, prevention is considered the best approach to fight it at present time. Green Tea Catechins (GTCs) were proven effective at inhibiting cancer growth in several laboratory studies. We recently performed a pilot clinical trial in HG-PIN subjects showing that only 1/30 tumour was diagnosed in subjects treated for 1 year with 600 mg/die GTCs, while 9/30 cancers were found in placebo-treated men. CaP is an elusive disease, whose biological behaviour is difficult to predict. We have recently described and validated a RT-qPCR method based on a 8-genes signature that significantly discriminated benign tissue from CaP in both humans and TRAMP mice spontaneously developing CaP. In the animal model, also GTCs-resistant CaP was significantly discriminated from GTCs-sensitive CaP, i.e. responding to GTCs administration. Preliminary experiments in our laboratory have shown that this method can be successfully applied to a single tissue needle biopsy specimen in humans. The combination of these results may be of particular significance on the field. In fact, GTCs treatment for men at high risk of CaP as first line prevention therapy in combination with the 8-genes signature profiling in tissue needle biopsies for real time monitoring of patient's response might importantly change, in the near future, the clinical managing of this highly diffuse malignancy.
3
Content available remote

Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin

84%
Man Y.-M., Park J.-M., Kangwan N., Jeong M., Lee S., Cho J. Y., Ko W. J., Hahm K. B.
Journal of Physiology and Pharmacology
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2015
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tom 66
|
nr 2
4

Molecular mechanisms of cancer-preventive effects of garlic organosulfur compounds

84%
Turek S.
Herba Polonica
|
2005
|
tom 51
|
nr 1-2
Pharmacological activity of garlic (Allium sativum L.) has been thoroughly evaluated for many years. The development of modern techniques in phytochemical analysis has ena­bled to detect a broad spectrum of organosulfur compounds which have an interesting biological activity. Recently, inhibition of carcinogenesis, observed at many stages, has seemed to be the most important feature. It has been established that garlic organosul­fur compounds can inhibit cancer development through multiple mechanisms, including mostly: modulating activity of carcinogen-metabolising enzymes, direct antiradical activi­ty, inhibiting cell proliferation and promoting apoptosis.
5

Cancer immunoprevention: current status and future directions

67%
Keshavarz-Fathi M., Rezaei N.
Archivum Immunologiae et Therapiae Experimentalis
|
2021
|
tom 69
|
nr 1
6

Analysis of expression of AIF and PARP-1 in cancerogenesis of HPV-positive cervix

67%
Warowicka A., Kwasniewska A., Sobieraj M., Gozdzicka-Jozefiak A.
Bulletin of the Veterinary Institute in Puławy
|
2011
|
tom 55
|
nr 3
The mRNA expression of AIF and PARP-1 in HPV negative non-tumour epithelial cells and HPV-positive cervical cancer cells using the real-time PCR method was examined. An increased level of AIF and PARP-1 mRNA in cervical cancer cells in comparison to normal epithelial cells was demonstrated. These results suggest that changes in the mRNA expression level of AIF and PARP-1 might be involved in cervical cancer development. The analysis of these two factors may represent a new molecular tool for cervical cancer prevention in women with HPV persistent infection.
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