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Abnormalities in serum proteins in the course of babesiosis in dogs

100%

Zygner W., Gojska-Zygner O., Wedrychowicz H.

Bulletin of the Veterinary Institute in Puławy

2011

tom 55

nr 1

The objectives of this study were to evaluate the serum protein electrophoresis pattern in dogs infected with B. canis, and correlation between haematocrit and albumin/globulin ratio. The infection with B. canis was confirmed by PCR and sequencing of PCR products. Total serum protein concentrations were determined by a clinical chemistry analyser. Albumin, α₁-, α₂-, β₁-, β₂-, and γ-globulin concentrations were assayed by densitometric analysis after electrophoretic separation of serum proteins on agarose gel. The most common disorders in affected dogs were decreased α-globulin fractions, increased ß-globulin concentration, increased albumin/globulin (A/G) ratio, and hypoglobulinaemia. A decrease in ar and α₂-globulin concentration was detected accordingly in 54.8% and 32.3% of dogs. An increase in β₁- and β₂-globulin concentration, and increased A/G ratio was detected accordingly in 38.7%, 51.6%, and 38.7% of dogs. Hypoglobulinaemia was detected in 32.3% dogs. Changes detected in this study probably result from haemolysis, hypertransferrinaemia, increased C3a protein concentration (complement), and dehydration.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Gojska-Zygner O.

1 Wedrychowicz H.

1 Zygner W.

1 2011

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Abnormalities in serum proteins in the course of babesiosis in dogs