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Content available

Evaluation of biochemical and standard effects of acetaminophen in Lemna minor vs Lemna gibba

100%
Antunes S., Martins L., Santos J., Correia B., Goncalves F., Pinto G., Nunes B.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2013
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tom 94
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nr 2
2
Content available remote

Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis

84%
Galaly S. R., Ahmed O. M., Mahmoud A. M.
Journal of Physiology and Pharmacology
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2014
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tom 65
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nr 6
3

Biological and biochemical effects of organo-synthetic analogues of trypsin modulating oostatic factor [TMOF] on Aedes aegypti, Heliothis virescens and Plutella xylostella

67%
Borovsky D., Nauen R.
Pestycydy
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2007
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nr 3-4
17-26
The three-dimensional conformation of Aea-TMOF (Aedes aegypti Trypsin Modulating Oostatic Factor), a decapeptide (YDPAPPPPPP) isolated from mosquito ovaries that inhibits the translation of many trypsin-like serine proteases, e.g. in mosquitoes, flies and lepidopterans, was used as a model for the synthesis of 10 aromatic and aliphatic organic acid and ester analogues. The organic TMOF analogues were tested against herbivorous pest lepidopterans and larval Ae. aegypti. The compounds administered to microtiter plates or to leaf disks caused mortality to mosquito larvae and the diamondback moth, Plutella xylostella, larvae 3-6 days after treatment. The surviving diamondback moth larvae were sluggish, immobile and stopped feeding. A biochemical analysis showed that in larval P. xylostella the trypsin activity was low and correlated with the observed mortality. No activity was found against Heliothis virescens when four of the synthetic compounds that affected P. xylostella and Ae. aegypti were tested, although the decapeptide, TMOF, does affect trypsin biosynthesis in H. virescens.
4

Physiological and biochemical effect of pyriproxyfen on Indian meal moth Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae)

67%
Ghasemi A., Sendi J. J., Ghadamyari M.
Journal of Plant Protection Research
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2010
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tom 50
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nr 4
Insect growth regulators generally have a selective effect on the target insects and have practically no apparent side effect on non-target organisms especially vertebrates. Hence, insect growth regulators could be a suitable choice to control pests in stored products. Ten-day-old larvae of Indian meal moth Plodia interpunctella (Hübner) were expressed to the juvenile hormone analogue pyriproxyfen in order to have an effect on growth, metamorphosis, reproduction, lipid and protein contents of ovaries. The larvae were treated by 0.02, 0.04, 0.08, 0.16, and 0.3 ppm of JHA in an artificial diet where controls received acetone alone. The results indicated significant differences in duration of growth, mean longevity of hatched adults, percentage of emerged normal adults, abnormal pupae, hatched larvae and mean oviposition ratein addition to the lipid and protein of ovaries compared to the controls. An inhibition concentration of fifty (IF50) for prevention of emerging adults was recorded 0.134 ppm. Pyriproxyfen caused significant defects in the legs and wings of some adults and sever morphological changes in the ovaries of emerged adults. The results showed that pyriproxyfen may be applied as an insecticide to decrease the damage caused by Indian meal moth on stored products. Pyriproxyfen can be used with low side effects to humans.
5

Pharmacological and biochemical effects of Ginkgo biloba extract of learning, memory consolidation and motor activity in old rats

67%
Blecharz-Klin K., Piechal A., Joniec I., Pyrzanowska J., Widy-Tyszkiewicz E.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 2
217-231
Effect of administration of the standardized extract of Ginkgo biloba leaves (EGb 761) on learning, memory and exploratory behavior was estimated in water maze and hole-board tests. Rats (18-month old) received for three months EGb 761 at doses: 50, 100 and 150 mg/kg b.w. per day. After completion of the behavioral experiment, concentrations of neurotransmitters were estimated in selected brain regions. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the control. The increased level of 5-hydroxytryptamine (5-HT) in the hippocampus and 5-HIAA (5-HT metabolite) in the prefrontal cortex correlated positively with the retention of spatial memory. Positive correlation between platform crossings in SE during the probe trial and neurotransmitter turnover suggest improvement of spatial memory. Long-term administration of Ginkgo biloba extract can improve spatial memory and motivation with significant changes in the content and metabolism of monoamines in several brain regions.
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