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Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium

100%

Meler J., Grimling B., Pluta J.

Journal of Elementology

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2010

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tom 15

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nr 1

141-147

Dietary supplements contain not only macro- and microelements, but also elements which affect human metabolism. Many products available on the market contain chromium compounds together with chitosan used as a dietary supplement enhancing the digestion of lipids. The studies involved natural chitosan from krill available on the market, with the deacetylation degree of 85 to 95%, and dietary supplements containing chitosan (Vitana®, Hitec Nutrition®) as well as a product containing ionic chromium with niacin and several aminoacids — Chromdiet®). The study has determined the capability of binding fatty and bile acids by dietary supplements containing chitosan and chromium. The process of lipids and bile acids adsorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions. The findings prove that extracts of fatty acids and bile acids undergo adsorption by various kinds of adjuvant substances found in dietary supplements, which confirms a significant effect of these polymers on the bioavailability of fatty and bile acids in a human organism. The addition of chromium to a supplement does not effect the capability of chitosan to bind fatty and bile acids. Mean adsorption of bile acids by 1 g of the polymer (chitosan, inulin, fibre) ranges from 0.9 g to 1.79 g depending on the pH (which decreases the bioavailability of lipids by 15-30%).

2

Secretin, cholecystokinin and the biliary canalicular secretion in the rat

100%

Romanski K. W., Bochenek W. J., Unold J., Szczepaniak M.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 2

3

Sorption of bile acids and cholesterol by dietary fiber of carrots, cabbage and apples

100%

Gorecka D., Korczak J., Balcerowski E., Decyk K.

Electronic Journal of Polish Agricultural Universities. Series Food Science and Technology

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2002

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tom 05

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nr 2

Adsorption of common bile acids namely lithocholic (LCA), dexycholic (DCA) and cholic (CA) acids and cholesterol by fiber of carrots, cabbage and apples raw and after heat treatment, respectively, was estimated. It was shown that degree of bile acids adsorption depends on kind of the raw material, type of heat treatment and type of bile acids. Fiber carrots had higher sorption than cabbage and apples. Fiber of baked vegetable and apples had significantly higher sorption capacity in compare with boiled and steamed plants material. Lithocholic acid was adsorbed in higher degree than DCA and CA. The cholesterol was bound in the highest degree by fiber cabbage on compared to fiber carrots and apples. Heat treatment of plants material, especially baking, increased the sorption of cholesterol by fiber cabbage as well as carrots and apples.

4

The effect of nitric oxide donors and L-arginine on the gastric electrolyte barrier

100%

Szlachcic A., Bilski R., Dziadus-Sokolowska A., Michalski J., Mroczka J.

Journal of Physiology and Pharmacology

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2001

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tom 52

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nr 2

5

Adsorption of bile acids and cholesterol by dry grain legume seeds

100%

Gorecka D., Korczak J., Flaczyk E.

Polish Journal of Food and Nutrition Sciences

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2003

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tom 12/53

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nr 1

The aim of the study was to estimate sorption degree of selected bile acids (lithocholic acid - LCA and cholic acid - CA) with 1 mmol/L and 6 mmol/L concentration as well as that of cholesterol by legumes. It was shown that bile acids sorption degree depended on the variety of seeds (the highest sorption ability had pea, while lentil showed the lowest one), grinding degree (bile acids were bound better by big particles) and the kind of acid (LCA acid with 6 mmol/L concentration was bound to a greater extent, independently on the variety of seeds and grinding degree). Next, the best binding ability of cholesterol was reported for bean, while the lowest one for soybean. Development of sorption surface of the investigated seeds significantly influenced extension of cholesterol binding ability.

6

Helicobacter pylori infection and the concentration of bile acids in the gastric juice in patients after cholecystectomy

100%

Kopanski Z., Brandys J., Wasilewska-Radwanska M., Schlegel-Zawadzka M., Cienciala A., Jung A., Kuc T.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 1

7

The influence of gastrointestinal hormone infusion upon the change of lithogenic index value in the rat

100%

Romanski K. W., Bochenek W. J.

Polish Journal of Veterinary Sciences

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1998

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tom 01

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nr 1

Rats, after cannulation of the common bile duct, duodenum and vena cava posterior were infused i.d. with sodium taurocholate to partially maintain the enterohepatic circulation of bile acids. Four-h i.V. infusions of glucagon, Boots secretin, Boots CCK and OP-CCK were continued together with bile acid administration. The bile was collected throughout the experiment and the bile volume, bile acid, phospholipid and cholesterol content in bile were determined. From these results molar lipid per cent and the lithogenic index were computed. During glucagon administration the lithogenic index was enhanced and molar per cent of phospholipids and cholesterol was greater, and that of bile acids was lower, than in rats deprived of hormone infusion. The effect of secretin upon the lithogenic index and the proportion of lipids was similar, although the rate of bile acid secreted was almost twice as high than that during glucagon infusion. When CCK was infused, despite enhanced per cent of bile acids, the lithogenic index was also higher than in the control group. No significant changes in both molar lipid composition and the lithogenic index were obtained when OP-CCK was applied. It is proposed that gastrointestinal hormones can affect bile lithogenicity through alterations of biliary lipid secretion.

8

Bile acids are multifunctional modulators of the Barrett’s carcinogenesis

80%

Burnat G., Majka J., Konturek P. C.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 2

Bile salts play an important pathogenic role in the development of Barrett adenocarcinoma (BA). However, the precise role of different bile salts in this process is still unknown. The aim of the present study was to compare the effects of two different bile salts, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) on the expression of COX-2, CDX-2 and DNA repair enzymes (MUTYH, OGG-1) in the Barrett epithelial cancer cells (OE-19). OE-19 cells were incubated with DCA or UDCA (100 µM or 300 µM at pH=7.0) over 24 h. To investigate the involvement of NFB, in separate experiments the cells were incubated with DCA in the presence of proteosome inhibitor (MG-132). Cells cycle and apoptosis were analyzed by FACS analysis. After incubation of OE-19 cells with bile salts, the expression of mRNA of COX-2, DNA repair enzymes (MUTYH, OGG-1) and caudal-related homebox transcription factor CDX-2 were measured by quantitative RT-PCR. OE-19 cell were also transfected with siRNA-RelA (p65) to asses effect of NFB inactivation on COX-2 and CDX2 expression. DCA caused a stronger reduction in cell survival of OE-19 cells than UDCA. In addition, DCA stimulated directly the translocation of NFB p65 (active form) in the nuclei of OE-19 cells. DCA caused stronger than UDCA stimulation of the COX-2 mRNA expression in these cells and this effect was significantly attenuated by the addition of inhibitor of NFB activity (proteosome inhibitor MG-132). siRNA-RelA reduced expression not only of NFB but also expression of COX-2 as well as CDX-2 mRNA. DCA caused stronger downregulation of mRNA for DNA repair enzymes MUTYH and OGG-1 than UDCA. In contrast, UDCA induced stronger CDX-2 mRNA expression than DCA in OE-19 cells. We conclude that bile salts are involved in the carcinogenesis of Barrett adenocarcinoma via inhibition of DNA repair enzymes and induction of COX-2 and this last effect is, at least partly, mediated by NFB. DCA shows carcinogenic potential due to high upregulation of COX-2, CDX-2 and downregulation of DNA repair enzymes.

9

Aspirin’s ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine

80%

Lichtenberger L. M., Phan T., Okabe S.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 4

10

Biological role of liver X receptors

71%

Baranowski M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 7

Ograniczanie wyników

Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium

Secretin, cholecystokinin and the biliary canalicular secretion in the rat

Sorption of bile acids and cholesterol by dietary fiber of carrots, cabbage and apples

The effect of nitric oxide donors and L-arginine on the gastric electrolyte barrier

Adsorption of bile acids and cholesterol by dry grain legume seeds

Helicobacter pylori infection and the concentration of bile acids in the gastric juice in patients after cholecystectomy

The influence of gastrointestinal hormone infusion upon the change of lithogenic index value in the rat

Bile acids are multifunctional modulators of the Barrett’s carcinogenesis

Aspirin’s ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine

Biological role of liver X receptors