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1
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Divergent effects of bicuculline and picrotoxin on ketamine-induced apneustic breathing

100%
Budzinska K.
Journal of Physiology and Pharmacology. Supplement
|
2005
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tom 56
|
nr 4
39-46
This study tested the potential role of inhibitory neurotransmission in the mechanism of apneustic respiration evoked by ketamine, an NMDA receptors antagonist. In the experiments performed in anesthetized, paralyzed, and ventilated cats, ketamine, in a dose of 0.5 mg/kg, was administered before and after GABAA receptor blockade with picrotoxin or bicuculline; all agents were given intravenously. Ketamine elicited a transient, hourlong apneustic respiration consisting of an increase in inspiratory duration and a decrease in inspiratory neural amplitude. After prior administration of picrotoxin, but not bicuculline, the maximum apneustic-like prolongation of inspiration evoked by ketamine was considerably reduced. The results suggest that the GABA receptor subunits specifically sensitive to picrotoxin play a role in shaping the ketamine-induced apneustic breathing.
2
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Influence of several convulsants on the protective activity of a non-competitive AMPA-kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice

84%
Borowicz K. K., Swiader M., Zgrajka W., Sawulski C., Turski W. A., Czuczwar S. J.
Journal of Physiology and Pharmacology
|
2002
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tom 53
|
nr 4,2
Aminophylline (50-100 mg/kg) and strychnine (0.125-0.5 mg/kg) significantly raised the ED50 values of LY 300164 against maximal electroshock in mice, from 4 to 8 mg/kg (aminophylline 100 mg/kg) and from 3.6 to 11.5 mg/kg (strychnine 0.5 mg/kg). Also, aminophylline (25-50 mg/kg) and strychnine (0.125-0.25 mg/kg) increased the ED50 value of lamotrigine in this test, for instance from 5.5 to 8.0 mg/kg (aminophylline 50 mg/kg) and from 5.2 to 8.9 mg/kg (strychnine 0.25 mg/kg). Moreover, the ED50s values of aminophylline and strychnine for the reduction of the anticonvulsant effect of LY 300164 (7 mg/kg, the dose equal to its ED97 value against maximal electroshock) were 79.9 and 0.2 mg/kg, respectively. The respective ED50 values for the inhibition of the antiseizure action of lamotrigine were 40.9 and 0.2 mg/kg. Neither bicuculline nor picrotoxin affected the protective action of LY 300164 or lamotrigine. Strychnine significantly lowered the plasma concentrations of LY 300164 and this my point to a pharmacokinetic mechanism of the observed interaction. Aminophylline did not affect the plasma concentrations of the studied anticonvulsant drugs and strychnine - that of lamotrigine, so a pharmacokinetic interaction does not seem probable. The present results indicate that the potential of aminophylline and strychnine to attenuate the anticonvulsant activity of conventional antiepileptics is extended to LY 300164 and lamotrigine.
3

Cholinergic-GABAergic interaction in the production of EEG theta oscillations in rat hippocampal formation in vitro

84%
Golebiewski H., Eckersdorf B., Konopacki J.
Acta Neurobiologiae Experimentalis
|
1996
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tom 56
|
nr 1
4

Long-term potentiation and long-term depression of horizontal connections in rat motor cortex

84%
Hess G., Donoghue J. P.
Acta Neurobiologiae Experimentalis
|
1996
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tom 56
|
nr 1
5

Bicuculline administration into ventromedial hypothalamus: effects on fear and regional brain monoamines and GABA concentrations in rats

67%
Zagrodzka J., Romaniuk A., Wieczorek M., Boguszewski P.
Acta Neurobiologiae Experimentalis
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2000
|
tom 60
|
nr 3
6

Bicuculline, AP-7 and behavioral activity in rats

67%
Car H., Kuziemka-Leska M., Wisniewski K.
Acta Neurobiologiae Experimentalis
|
1998
|
tom 58
|
nr 2
7

Strychnine antagonizes GABA-evoked 36 CI- uptake in membrane vesicles from rat and rabbit cerebral cortex

59%
Puka M., Lazarewicz J. W.
Acta Neurobiologiae Experimentalis
|
1993
|
tom 53
|
nr 4
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