Two-hundred-sixty-five young cattle of both sexes, progeny of thirty-one Polish Friesian AI bulls were genotyped for growth hormone (GH), κ-casein (CSN3), and β-lactoglobulin (LGB) gene variants.Associations were evaluated between genetic variants in the three loci and concentration of triiodothyronine (T3), thyroxine (T4), insulin (Ins), glucose (Glu), urea (Ur), creatinine (Cr), cholesterol (Chol), as well as activity of alkaline phosphatase (AP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Only the level of Ins and Ur were not found related to the loci considered. The level of T3 was affected by the interaction between the GH and LGB loci, while that of T4 by the epistasis of GH, CSN3 and LGB. Cr and Chol levels depended on both CSN3 and LGB as well as their interaction. GH × CSN3 loci were found involved in the AP, all the three loci in ALT, and GH × LGB in AST activity moulding.
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