Wyniki wyszukiwania

1

Beta-amyloid a choroba Alzheimera

100%

Golabek A. A.

Wszechświat

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1997

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tom 98

|

nr 09

211-216

2

Carboxyl terminal fragment of beta-amyloid precursor protein: electrophysiological effects and cellular toxicity

84%

Fraser S. P., Bryan A. A., Diss J. K. J., Kim J. H., Kim S. H., Suh Y. H., Djamgoz M. B. A.

Cellular and Molecular Biology Letters

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1997

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tom 02

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nr 2

Alzheimer's disease (AD) is characterized by deposition of β-amyloid (Aβ) in areas of the brain. Aβ is a metabolic fragment of the β-amyloid precursor protein (βAPP). Genetic evidence has linked βAPP to AD, and there is increasing evidence that fragments from βAPP are neurotoxic. Aβ, the main research focus, has been shown to induce depolarizing ion channel activity. Involvement of other cleaved products from βAPP are less clear. We have investigated the 105 amino acid C-terminal peptide (CT105) (containing the full sequence Aβ), an alternative fragment linked with cellular toxicity. CT105 induced non-selective ionic currents in Xenopus oocytes (a model cell used in cell signalling studies) and was toxic to oocytes and mammalian cortical neurones. These results suggest possible involvement of CT105 in inducing the neural toxicity characteristic of AD.

3

Zespol utraty funkcji poznawczych u starych psow

67%

Kwiatkowska M., Pomianowski A.

Magazyn Weterynaryjny

|

2009

|

tom 18

|

nr 05

544-546

4

Zdjąć klątwę alzheimera

67%

Stix G.

Świat Nauki

|

2015

|

nr 06

5

Molekularne mechanizmy choroby Alzheimera

67%

Bartoszewska M.

Postępy Biologii Komórki

|

2008

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tom 35

|

nr 3

333-350

6

Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system

67%

Hauff K., Zamzow C., Law W. J., De Melo J., Kennedy K., Los M.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

|

nr 4

7

Dysfunkcje mitochondriów w chorobach neurodegeneracyjnych: potencjalny punkt uchwytu dla leków neuroprotekcyjnych

59%

Greda A., Jantas D.

Postępy Biologii Komórki

|

2012

|

tom 39

|

nr 3

8

Zalążki demencji

59%

Walker L. C., Jucker M.

Świat Nauki

|

2013

|

nr 06

9

Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: the role of structural effects

59%

Pogocki D.

Acta Neurobiologiae Experimentalis

|

2003

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tom 63

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