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Age-related profile of beta-N-acetylhexosaminidase glycosylation in rat liver

100%

Litynska A., Przybylo M.

Acta Biochimica Polonica

1998

tom 45

nr 3

β-N-acetylhexosaminidase was prepared from a liver lysosomal fraction obtained from rats between 18 days of gestation (group I) and 72 weeks of age (groups II-VI). A glycan chain analysis was performed after an electrophoresis and blotting, followed by a very sensitive detection system with highly specific digoxigenin-labelled lectins. The presence of high-mannose /hybrid type glycans, as well as their fucosylated forms was shown in all the experimental groups. Complex-type glycans with terminal sialic acid or galactose were present in all the groups except for 1-week-old rats in which only a positive reaction with lectins from Galanthus nivalis and Aleuria aurantia - was observed. Thus it may be assumed that age-related changes in the glycosylation pattern occur on the first days after birth.

Testicular activity of acid glycosidases in cocks of different breeds

100%

Droba B.

Roczniki Naukowe Zootechniki

2000

tom 27

nr 4

Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures

59%

Zalewska A., Brzoska M. M., Marciniak J., Karaszewska K., Zwierz K., Moniuszko-Jakoniuk J.

Acta Biochimica Polonica

2004

tom 51

nr 3

Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of ß-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, ß-N-acetylhexosa- minidase showed the highest activity. The activities of a-mannosidase and ß-galacto- sidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Roczniki Naukowe Zootechniki

1 Brzoska M. M.

1 Droba B.

1 Karaszewska K.

1 Litynska A.

1 Marciniak J.

1 Moniuszko-Jakoniuk J.

1 Przybylo M.

1 Zalewska A.

1 Zwierz K.

1 2004

1 2000

1 1998

Wyniki wyszukiwania

Age-related profile of beta-N-acetylhexosaminidase glycosylation in rat liver

Testicular activity of acid glycosidases in cocks of different breeds

Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures