Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 7

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  beta cell
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Application of the coupled harmonic oscilators model to the description of beta-cells of the pancreatic Langerhans islets

100%
Sikorska-Piwowska Z., Kukwa A., Patyk Z.
Folia Morphologica
|
1996
|
tom 55
|
nr 4
2

The effect of maternal diabetes on pancreatic islets in newborn rats: a quantitative and immunocytochemical study

84%
Badawoud M. H. M.
Folia Morphologica
|
2006
|
tom 65
|
nr 2
152-156
The effect of diabetes during pregnancy on the endocrine pancreas of the newborn has been studied before, but a detailed morphometric immunocytochemical study is not available. The aim of this study was to investigate the effect of maternal diabetes on the morphology of islets in newborn rats. Pancreatic sections were stained by the indirect immunoperoxidase method to localise the insulin-producing β-cells and were used for morphometric analysis. The islet volume density, diameter and volume and the absolute islet cell number were significantly greater in the diabetic group than in controls. The β-cell volume density was significantly lower in the diabetic group, although the β-cell nuclear diameter and volume did not differ significantly in this group. The results obtained from this investigation indicate that maternal diabetes induces islet hypertrophy in newborn offspring and causes an increase in the total islet cell number.
3

Effects of olive leaf polyphenols against H2O2 toxicity in insulin secreting β-cells

67%
Cumaoglu A., Rackova L., Stefek M., Kartal M., Maechler P., Karasu C.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 1
In pancreatic β-cells, although H2O2 is a metabolic signal for glucose stimulated insulin secretion, it may induce injury in the presence of increased oxidative stress (OS) as in the case of diabetic chronic hyperglycemia. Olea europea L. (olive) leaves contain polyphenolic compounds that may protect insulin-secreting cells against OS. The major polyphenolic compound in ethanolic olive leaf extract (OLE) is oleuropein (about 20 %), thus we compared the effects of OLE with the effects of standard oleuropein on INS-1 cells. The cells were incubated with increasing concentrations of OLE or oleuropein for 24 h followed by exposure to H2O2 (0.035 mM) for 45 min. H2O2 alone resulted in a significantly decreased viability (MTT assay), depressed glucose-stimulated insulin secretion, increased apoptotic and necrotic cell death (AO/EB staining), inhibited glutathione peroxidase activity (GPx) and stimulated catalase activity that were associated with increased intracellular generation of reactive oxygen species (ROS) (fluorescence DCF). OLE and oleuropein partly improved the viability, attenuated necrotic and apoptotic death, inhibited the ROS generation and improved insulin secretion in H2O2-exposed cells. The effects of oleuropein on insulin secretion were more pronounced than those of OLE, while OLE exerted a stronger anti-cytotoxic effect than oleuropein. Unlike OLE, oleuropein had no significant preserving effect on GPx; however, both compounds stimulated the activity of catalase in H2O2-exposed cells. These findings indicate different modulatory roles of polyphenolic constituents of olive leaves on redox homeostasis that may have a role in the maintenance of β-cell physiology against OS.
4

Islet transplantation: factors in short-term islet survival

67%
Deters N. A., Stokes R. A., Gunton J. E.
Archivum Immunologiae et Therapiae Experimentalis
|
2011
|
tom 59
|
nr 6
5
Content available remote

Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions

67%
Kaczmarek P., Skrzypski M., Pruszynska-Oszmalek E., Sassek M., Kolodziejski P. A., Billert M., Szczepankiewicz D., Wojciechowicz T., Maechler P., Nowak K. W., Strowski M. Z.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 5
6

The potential role of Kruppel-like zinc-finger protein glis3 in genetic diseases and cancers

67%
Chou C.-K., Tang C.-J., Chou H.-L., Liu C.-Y., Ng M.-C., Chang Y.-T., Yuan S.-S. F., Tsai E.-M., Chiu C.-C.
Archivum Immunologiae et Therapiae Experimentalis
|
2017
|
tom 65
|
nr 5
7

Is lack of peripheral tolerance induction a cause for diabetes in the non-obese diabetic mouse?

67%
Lund T., Strid J.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 5
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.