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Time-dependent modification of model membrane properties by benzylammonium chlorides

100%

Gabrielska J., Sarapuk J., Kleszczynska H., Przestalski S.

Polish Journal of Environmental Studies

1993

tom 02

nr 3

The nature of the interaction between some strong antifungal compounds and model membranes was studied. It was found that these compounds (N-dodecyl-N,N-dimethyl-N-/3- (β-methyl-β-nitrovinyl 1-6-methoxybenzyl/ammonium chloride and its derivatives) significantly change the properties of liposomes, planar lipid bilayers (BLM) and erythrocytes. The changes observed (i.e., release of praseodymium ions from liposomes and gradually diminished stability of BLM) in the presence of the compounds studied, as well as hemolysis of red blood cells, were time-dependent. It was also found that they depended on the polar head structure of the compounds.

Ograniczanie wyników

1 Polish Journal of Environmental Studies

1 Gabrielska J.

1 Kleszczynska H.

1 Przestalski S.

1 Sarapuk J.

1 1993

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Time-dependent modification of model membrane properties by benzylammonium chlorides