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Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine

100%

Nowak P., Kostrzewa R. M., Kwiecinski A., Bortel A., Labus L., Brus R.

Journal of Physiology and Pharmacology

2005

tom 56

nr 2

To determine whether behavioral sensitization produced by prolonged D-amphetamine administration affects susceptibility of nigrostriatal dopaminergic neurons to the neurotoxic actions of 6-hydroxydopamine (6-OHDA), rats were treated daily from the 23 rd day after birth for 11 consecutive days with D-amphetamine (1.0 mg/kg s.c.) or saline. On the last day of treatment, one group primed with D-amphetamine and one control group of rats were tested to confirm behavioral sensitization development. The remaining animals were additionally treated on the 34 th day (one day after the last D-amphetamine injection) with 6-OHDA HBr (300 µg in 10 µl i.c.v., salt form, half in each lateral ventricle) or its vehicle. Four weeks later the levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-metoxytyramine (3-MT), as well as 5-hydroxytrypatmine (5-HT) and its metabolite 5-hydroxyindoleacteic acid (5-HIAA) were assayed in the striatum, by HPLC/ED. In rats with behavioral sensitization, 6-OHDA reduced endogenous dopamine and its metabolites content to a comparable degree in comparison to controls. This finding indicates that presumed up-regulation of the dopamine transporter in the behaviorially sensitized rats did not increase the neurotoxicity of a high dose of 6-OHDA.

Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat

84%

Gralewicz S.

Acta Neurobiologiae Experimentalis

2002

tom 62

nr 2

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Journal of Physiology and Pharmacology

1 Bortel A.

1 Brus R.

1 Gralewicz S.

1 Kostrzewa R. M.

1 Kwiecinski A.

1 Labus L.

1 Nowak P.

1 2005

1 2002

Wyniki wyszukiwania

Neurotoxic action of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-amphetamine

Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat