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Urea-creatinine ratio in urine of autistic children is often abnormal

100%

Turska-Klimont L., Szot Z., Matuszkiewicz A.

Polish Journal of Environmental Studies

1999

tom 08

nr 5

Homocysteine level in urine of autistic and healthy children

67%

Kaluzna-Czaplinska J., Michalska M., Rynkowski J.

Acta Biochimica Polonica

2011

tom 58

nr 1

Homocysteine is an amino acid which plays several important roles in human physiology and is an important biomarker for possible deficiencies of various vitamins (vitamin B6 and B12, folic acid). In this work GC-MS method was used to determine the levels of homocysteine in the urine of autistic and healthy children. The levels of homocysteine in urine samples from 34 autistic and 21 healthy children were 2.36 ± 1.24 and 0.76 ± 0.31 (mmol∙mol-1 creatinine), respectively. The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B6 and B12 in nutrition of these children. The results of this work were taken into consideration in the nutrition of autistic children treated in the Navicula Centre of Diagnosis and Therapy of Autism in Łódź (Poland).

Hyperhomocysteinemia among Omani autistic children: a case-control study

67%

Ali A., Waly M. I., Al-Farsi Y. M., Essa M. M., Al-Sharbati M. M., Deth R. C.

Acta Biochimica Polonica

2011

tom 58

nr 4

High serum homocysteine (Hcy) level is regarded as an indicator for impairment of folate-dependent methionine cycle and is associated with oxidative stress. In a case control study, we evaluated eighty 3-5 years old Omani children (40 diagnosed with Autism Spectrum Disorder and 40 their age and gender matched controls) for their fasting serum homocysteine levels as a biomarker of Autism Spectrum Disorder (ASD). Serum folate and vitamin B12 status were also evaluated. The serum homocysteine was measured using an enzyme immunoassay (EIA) technique whereas folate and vitamin B12 were measured using an automated random access immune-assay system. The results indicated that mean serum Hcy levels were significantly (P < 0.05) higher in autistic children (20.1 ± 3.3 µmol/L) as compared to controls (9.64 ± 2.1 µmol/L). Significantly (P < 0.05) lower serum folate (1.8 ± 0.4 µg/L) and vitamin B12 (191.1 ± 0.9 pg/mL) levels were observed in autistic children as compared to controls (6.1 ± 0.6 µg/L and 288.9 ± 1.3 pg/mL, respectively). The levels of homocysteine in autistic children were also much higher as compared to normal reference values (5-15 µmol/L). The results suggest that high fasting serum homocysteine and low folate and vitamin B12 levels could be used as clinical biomarkers for an early diagnosis and management of ASD.

Ograniczanie wyników

2 Acta Biochimica Polonica

1 Polish Journal of Environmental Studies

1 Al-Farsi Y. M.

1 Al-Sharbati M. M.

1 Ali A.

1 Deth R. C.

1 Essa M. M.

1 Kaluzna-Czaplinska J.

1 Matuszkiewicz A.

1 Michalska M.

1 Rynkowski J.

1 Szot Z.

1 Turska-Klimont L.

1 Waly M. I.

2 2011

1 1999

Wyniki wyszukiwania

Urea-creatinine ratio in urine of autistic children is often abnormal

Homocysteine level in urine of autistic and healthy children

Hyperhomocysteinemia among Omani autistic children: a case-control study