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1

Zmiany metaboliczne zachodzące u pszenicy zwyczajnej (Triticum aestivum L.) w wyniku interakcji z grzybami Trichoderma

100%
Witaszak N., Sawikowska A., Blaszczak L., Marczak L.
Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin
|
2019
|
nr 285
2
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Konferencja naukowa "Parazytozy w aspekcie środowiskowym i molekularnym"

75%
Wojtkowiak-Giera A.
Wiadomości Parazytologiczne
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2011
|
tom 57
|
nr 1
3

Molekularne aspekty aktywności biologicznej selenu

75%
Ksiazek I.
Postępy Biologii Komórki
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2015
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tom 42
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nr 1
4

Udział wybranych genów w nowotworzeniu na poziomie molekularnym

75%
Madej J. A.
Medycyna Weterynaryjna
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2019
|
tom 75
|
nr 08
The paper describes the influence of selected genes on neogenesis, including their expression, RNA transformation, translation and transcription. The role of adhesive molecules, extracellular matrix, cytoskeleton and signal conduction in neoplastic induction is described. External stimuli, internal factors and disturbances in DNA repair can cause cell mutations (fig. 1). An accumulation of various factors in different gene classes, together with their amplification, leads to tumour formation. Neoplastic cells undergo a dominant mutation, thereby gaining a new function, or cumulate recessive mutations which cause the loss of a function. This is particularly true in genetic anomalies associated with the cadherin system, e.g. the loss of E-cadherin expression in mammary cancer. The loss of E-cadherin or catenin expression causes the loss of cell connections, which facilitates metastasizing. Cells in metastases often show genetic disorders, a more malignant phenotype and increased drug resistance, which worsens clinical prognosis. The search for new anti-neoplastic drugs for humans is based on molecular studies and mice experimental models. The animals in these models show a phenotype corresponding with specific human diseases, e.g. Pax gene mutation in sarcomas and carcinomas, antisense DNA therapy (in Burkitt’s lymphoma or chronic leukaemia) or induction of retroviral vectors (thymidine kinase gene) in herpes virus (HS-th) in proliferating cells in multiform glioblastoma.
5

Molekularne aspekty oraz współczesna diagnostyka i leczenie wrodzonych wad serca

63%
Jankowska P., Bobkowska A., Bobkowski W., Siwinska A.
Postępy Biologii Komórki
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2013
|
tom 40
|
nr 1
6

Molekularne aspekty nowotworzenia - wybrane zagadnienia

63%
Madej J. A.
Medycyna Weterynaryjna
|
2009
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tom 65
|
nr 05
291-295
At the basis of neoplastic processes there lie molecular lesions i.e. non-lethal, multi-stage damage to genetic material. The paper describes damage to nuclear chromatin and the role of RNA in neoplasia as well as the involvement of adhesion molecules, extracellular matrix (ECM), signal transduction (including humoral signals) and the role of cell cycle in the process. The significance of molecular techniques in the diagnosis of tumours was also shown.
7

Molekularne aspekty interakcji plemnika z oocytem u ssaków

63%
Kempisty B., Bukowska D., Wozna M., Sikora J., Jaskowski J. M.
Medycyna Weterynaryjna
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2010
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tom 66
|
nr 08
s.544-546,bibliogr.
The process of spermegg fusion is one of the most important mechanisms involved in successful fertilization. Studies conducted in an effort to elucidate this process are mainly focused on analyzing the interaction between the membrane proteins of male and female gametes. In the last few years, the genes coding proteins which may play an integral role in the process of sperm-egg binding and fusion have been identified. It has been suggested that sperm ADAMs family proteins are involved in this process. The sperm specific fertilin α, fertilin β and cyritestin are among this protein family. The oocyte’s integrins, which are included in egg cell membrane, form receptors specific for those proteins. The other group of proteins, which are connected with sperm-egg fusion, are specific for oocyte CD9 protein and sperm epididymal protein DE. The aim of this review was to present the characteristics of several proteins involved in the sperm-egg interaction process. The exploration of fertilization mechanisms may become the basic element that will improve assisted reproductive techniques and in vitro fertilization in mammals.
8

Molekularne aspekty procesu dojrzewania jądrowego i cytoplazmatycznego oocytów u świń

63%
Bukowska D., Kempisty B., Ciesiolka S., Piotrowska H., Antosik P., Wozna M., Porowski S., Ociepa E., Maryniak H., Jaskowski J. M., Bryja A., Nowicki M.
Medycyna Weterynaryjna
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2013
|
tom 69
|
nr 08
The development of pig reproductive biotechnology has made it possible to use this species not only as farm animals but also as important models in biomedical research. Systems based on pig embryos from in vitro fertilization (IVF) are used much more frequently, although the quality of these embryos differs from those produced by in vivo fertilization. The most frequent problems in the IVF procedure are disturbances in both nuclear and cytoplasmic oocyte maturation, and the mechanism of polyspermy specific for this species. Although there has been progress in increasing the number of oocytes produced by in vitro maturation processes, the quality of embryos from these oocytes and their developmental competence is still unsatisfactory. It has been suggested that the most important factor in this process is the establishment of optimal conditions for the development and maturation of oocytes. In this review the authors attempt to explain the molecular basis of oocyte maturation, meiosis resumption, and meiotic spindle assembly. The article is also an opportunity to use the knowledge gained to date in order to increase the efficiency of animal breeding, to evaluate the genetic value of oocytes, as well as to improve assisted reproductive techniques (ART).
9

Wybrane aspekty komórkowych mechanizmów regulujących interakcję plamnika i komórki jajowej u ssaków

51%
Bukowska D., Kempisty B., Zaorska K., Antosik P., Pawlowska J., Nowicki M.
Medycyna Weterynaryjna
|
2014
|
tom 70
|
nr 05
Fertilization is a complex process which includes the recognition and fusion of an oocyte and a sperm and the development of a zygote that contains a double set of chromosomes. Each step in this process is precisely controlled at the molecular level in a cascade of biochemical reactions (cortical and acrosome reactions) that determine the future of both gametes. Biochemical reactions not only reorganize gametes in morphological, physiological, and biochemical terms, but also prepare them for the future coordinated communication. Molecular aspects of gamete development and fertilization include the reorganization of the cell membrane and ligand-receptor reactions that affect the recognition of gametes and lead to the formation of pronuclei and zygote development. This article discusses several aspects of the recognition, interaction, and fusion of a sperm and an oocyte. It also describes biochemical reactions involved in the development of gametes that are capable of fertilization.
10

Molekularne podłoże dziedzicznych nefropatii u psów rasy spaniel

51%
Wasielewska M., Szatkowska I., Czerniawska-Piatkowska E., Zaborski D.
Medycyna Weterynaryjna
|
2019
|
tom 75
|
nr 12
The molecular background of hereditary nephropathies in English Cocker Spaniels and Springer Spaniels remained unclear until the beginning of the 21st century. It was only the discovery of an association between these diseases and Alport syndrome in humans that made it possible to identify the genes potentially responsible for nephropathies in dogs. Eventually, two mutations were identified in the COL4A4 gene coding for the alpha chains of collagen IV, the main component of the glomerular basement membrane (GBM). This review presents the molecular mechanism resulting from the aforementioned mutations, the signs of disease, functions of the GBM, and breeding aspects.
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