Wyniki wyszukiwania

1

Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats

100%

Pires W., Wanner S. P., La Guardia R. B., Rodrigues L. O. C., Silveira S. A., Coimbra C. C., Marubayashi U., Lima N. R. V.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 1

The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (Ttail), core temperature and blood pressure were measured after injection of 2 µL of 5 x 10-3 M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, Ttail was measured using a thermistor taped to the tail and intraperitoneal temperature (Tb) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 ± 4 mmHg Phy vs. 121 ± 3 mmHg Sal; P < 0.001) and higher Ttail (26.4 ± 1.0° C Phy vs. 23.8 ± 0.5° C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in Tb compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.

2

The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in hemorrhagic shock in rats

84%

Sowa P., Adamczyk-Sowa M., Zwirska-Korczala K., Namyslowski G., Misiolek M., Pierzchala K.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 2

3

Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats

84%

Jochem J., Zwirska-Korczala K., Zabielski R., Kato I., Kuwahara A.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 11

115-124

Orexin A influences the central cardiovascular regulation, since after intracerebroventricular (icv) administration it evokes short-lasting increases in mean arterial pressure (MAP) and heart rate (HR) in normotensive animals. The aim of the present study was to examine haemodynamic effects of orexin A in haemorrhage-shocked rats. Experiments were carried out in anaesthetized Wistar rats subjected for a critical irreversible haemorrhagic hypotension of 20-25 mmHg, which resulted in the death of all saline icv-treated control animals within 30 min. Orexin A (0.5-1.5 nmol; icv) administered at 5 min of critical hypotension evoked dose-dependent long-lasting increases in MAP, HR and renal, mesenteric and hindquarters blood flows, with a 100% survival of 2 h after treatment (1.5 nmol; icv). Changes in MAP and peripheral haemodynamics were inhibited by intravenous pretreatment with alpha1- and alpha2-adrenoceptor antagonists prazosin (0.5 mg/kg) and yohimbine (1.0 mg/kg), respectively. Moreover, both antagonists significantly decreased the survival rate to 16.6 and 33.3% (P<0.05 vs. orexin A [1.5 nmol]-treated group). In contrast, ß-adrenoceptor antagonist propranolol (1.0 mg/kg) completely blocked orexin A-induced HR changes, without influence on MAP, peripheral blood flows and the survival rate. Therefore, we conclude that centrally acting orexin A evokes the resuscitating effect in haemorrhage-shocked rats due to the activation of the sympathetic nervous system.

4

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

84%

Jochem J., Savci V., Filiz N., Rybus-Kalinowska B., Fogel W. A., Yalcin M.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 1

37-43

Cytidine 5’-diphosphocholine (CDP-choline) is an endogenously synthesized mononucleotide which exerts a variety of physiological effects by altering central cholinergic transmission. Administered intracerebroventricularly (i.c.v.) or intravenously, it reverses haemorrhagic hypotension in rats, apparently by the activation of central cholinergic receptors. The study was undertaken to investigate the involvement of the central histaminergic system in CDP-choline-mediated reversal of haemorrhagic hypotension. Experiments were carried out in male ketamine/xylazine-anaesthetised Wistar rats subjected to haemorrhagic hypotension of 20-26 mmHg. CDP-choline (2 µmol; i.c.v.) administered at 5 min of critical hypotension produced a long-lasting pressor effect with increases in mean arterial pressure (MAP), heart rate (HR), and renal, hindquarters and mesenteric blood flows, resulting in a 100% survival at 2 h. The action was accompanied by approximately a 26% increase in extracellular histamine concentration at the posterior hypothalamus, as measured by microdialysis. Cardiovascular effects mediated by CDP-choline were almost completely blocked by pretreatment with H1 receptor antagonist chlorpheniramine (50 nmol; i.c.v.), but not with H2 receptor blocker ranitidine (25 nmol; icv) or H3/H4 receptor antagonist thioperamide (50 nmol; i.c.v.). In conclusion, the present results show that the central histaminergic system, through the activation of H1 histaminergic receptors, is involved in CDP-choline-induced resuscitating effect in haemorrhage-shocked rats.

5

Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats

84%

Jochem J., Altinbas B., Yalcin M., Ottani A., Giuliani D., Savci V., Kasperska-Zajac A., Guarini S.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 1

6

Spleen volume changes during adrenergic stimulation with low doses of epinephrine

84%

Brakovic D., Pivac N., Zubin Maslov P., Breskovic T., Damonja G., Dujic Z.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 5

7

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Role of the endogenous nitric oxide in the vasodilatory tone and CO2 responsiveness of the rostral ventrolateral medulla microcirculation in the rat

84%

Wolk R., Nowicki D., Sieminska J., Trzebski A.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 2

8

Effect of electrical stimulation of A and C fibres of the aortic nerves on arterial peripheral and cerebral blood pressure

84%

Schoenborn R., Dmowska M., Unkiewicz A., Modrzejewski E.

Folia Biologica

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1996

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tom 44

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nr 3-4

9

Cardiovascular response to vestibular stimulation in cyclic, situational and stereotypical complex coordination kinds of sports

67%

Nazarenko A. S., Chinkin A. S.

Central European Journal of Sport Sciences and Medicine

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2014

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tom 05

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nr 1

The aim of the work is the study of the dependence of cardiovascular system reaction to the vestibular stimulation on the peculiarities of movements in the above-mentioned kinds of sports. Vestibular reactions of 108 males were studied, 93 of which were involved in cyclic (middle and long distance jogging, cross-country skiing, swimming), situational (sports game) and difficult to coordinate movements of stereotypical sports (gymnastics). The above facts indicate that sports contribute to the adaptation to vestibular load and, as a consequence, the development of less severe autonomic reactions to vestibular stimulation. It is essential that the vestibular resistance develops not only in those sports in which the motor activity abounds in a corner acceleration but also in those species sports where such similar accelerations are minimal. The influence of the specifics of the motor activity in some sports is reflected in the value of response in tests with a change of a head position.

10

Increased serum urea to creatinine ratio and its negative correlation with arterial pressure in canine babesiosis

67%

Zygner W., Gojska-Zygner O.

Acta Parasitologica

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2014

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tom 59

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nr 3

The increase of the serum urea to creatinine ratio (UCR) was observed in dogs infected with Babesia canis. Previous studies have suggested that decrease of blood pressure can be one of the reasons for this phenomenon. In this work statistically significant increase of the UCR was observed in dogs with babesiosis. Comparison of the UCR between 23 azotaemic dogs and 25 non-azotaemic dogs infected with Babesia canis showed statistically significantly higher mean of the UCR in azotaemic dogs. Correlations between UCR and systolic, diastolic and mean arterial pressure (SAP, DAP and MAP) in 48 dogs infected with B. canis were negative (UCR and SAP: r = −0.3909; UCR and DAP: r = −0.3182; UCR and MAP: r = −0.3682) and statistically significant (p < 0.05). This result may indicate contribution of hypotension in the increase of the UCR in canine babesiosis. However, the correlations were not high, and there was no statistically significant correlation between UCR and arterial pressures in azotaemic dogs. Thus, it seems that decrease of blood pressure in dogs with babesiosis explains only partially the cause of increased UCR in infected dogs. The other authors suggested hyperureagenesis and myocardial injury as a potential reason for the increased UCR in canine babesiosis. Thus, further studies are needed to determine causes of increased UCR in dogs with babesiosis, especially on the connection between UCR changes and the concentrations of plasma cardiac troponins and ammonia, and the occurrence of occult blood on fecal examination.

11

Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats

67%

Kuczeriszka M., Badzynska B., Kompanowska-Jezierska E.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 11

179-185

The renal regulatory role of cytochrome P450 dependent metabolites of arachidonic acid (AA), vasodilator epoxyeicosatrienoic acids (EETs) and vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE), was examined in anaesthetised rats. We measured renal artery flow (RBF), cortical (CBF) and medullary (MBF) perfusion (laser-Doppler) and medullary tissue nitric oxide (NO, selective electrode), after non-selective inhibition of CYP-450 pathway with 1-aminobenzotriazole (ABT, 10 mg/kg i.v.) or after selective inhibition of 20-HETE synthesis with HET0016 (Taisho Co, Yoshino-cho, Japan), infused into renal artery at 0.3 mg/kg/h or into renal medulla at rates increasing from 0.15 to 1.5 mg/kg/h. ABT caused significant (by 13.7%) decrease in RBF without changing MBF. Renal arterial HET0016 increased MBF (not RBF or CBF) from 152±12 to 174±12 perfusion units (+16%, P<0.001), while medullary tissue nitric oxide was significantly increased (P<0.001). After renal medullary HET0016, renal perfusion indices were significantly higher than after HET0016 solvent (ß-cyclodextrin). Total renal blood flow seems to be under vasodilator control of EETs whereas renal medullary perfusion under tonic suppression by 20-HETE. The data document, for the first in the whole kidney studies, the functional antagonism of 20-HETE and NO.

12

Role of paraventricular nucleus vasopressin V1a receptors in the response to endothelin 1 activation of the subfornical organ in the rat

67%

Rossi N. F., Maliszewska-Scislo M.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 8

13

Increased pneumotoxicity of lipopolysaccharide from E.coli in nitric oxide deficient blood-perfused rat lungs

67%

Bartus J. B., Chlopicki S., Gryglewski R. J.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 4

14

The adrenal-renal vascular connection contributes to increase in renal vascular resistance during an experimental hypotension in the rat

67%

Ziecina R., Abramczyk P., Lisiecka A., Przybylski J.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 2

15

Atrial natriuretic peptide secretion following subarachnoid hemorrhage in spontaneously hypertensive rats

59%

Josko J., Hendryk S., Jedrzejowska-Szypulka H., Gwozdz B., Herman Z. S., Latka D., Kopec N.

Journal of Physiology and Pharmacology

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1996

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tom 47

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nr 4

Ograniczanie wyników

Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats

The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in hemorrhagic shock in rats

Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats

Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats

Spleen volume changes during adrenergic stimulation with low doses of epinephrine

Role of the endogenous nitric oxide in the vasodilatory tone and CO2 responsiveness of the rostral ventrolateral medulla microcirculation in the rat

Effect of electrical stimulation of A and C fibres of the aortic nerves on arterial peripheral and cerebral blood pressure

Cardiovascular response to vestibular stimulation in cyclic, situational and stereotypical complex coordination kinds of sports

Increased serum urea to creatinine ratio and its negative correlation with arterial pressure in canine babesiosis

Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats

Role of paraventricular nucleus vasopressin V1a receptors in the response to endothelin 1 activation of the subfornical organ in the rat

Increased pneumotoxicity of lipopolysaccharide from E.coli in nitric oxide deficient blood-perfused rat lungs

The adrenal-renal vascular connection contributes to increase in renal vascular resistance during an experimental hypotension in the rat

Atrial natriuretic peptide secretion following subarachnoid hemorrhage in spontaneously hypertensive rats