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p-ERK involvement in the neuroprotection exerted by ischemic preconditioning in rat hippocampus subjected to four vessel occlusion

100%
Kovalska M., Kovalska L., Mikuskova K., Tatarkova Z., Lehotsky J.
Journal of Physiology and Pharmacology
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2014
|
tom 65
|
nr 6
2

Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer

100%
Koda M., Kanczuga-Koda L., Reszec J., Sulkowska M., Famulski W., Baltaziak M., Kisielewski W., Sulkowski S.
Folia Morphologica
|
2004
|
tom 63
|
nr 3
Apoptosis and proliferation are processes associated with the development and progression of breast cancer. The sensitivity of tumour cells to the induction of apoptosis depends on the balance between pro- and anti-apoptotic proteins. The expression of Bak and Bcl-2 was examined using an immunohistochemical method in 71 primary breast cancers. Furthermore, Bcl-2 and Bak were assessed in the normal mammary gland as well as in benign mammary dysplasia adjacent to breast cancer. Positive immunostaining for Bcl-2 was observed in 77.8% of cases of normal breast epithelium (NBE), 93% of benign dysplasia without intraductal proliferation (BBD) as well as in 94% of intraductal proliferative lesions of the breast (BIPL). Expression of Bak was detected in 39% of cases of NBE, 45% of BBD and in 67% of BIPL. In breast cancer Bcl-2 and Bak expression was found in 83% and 70% of the cases studied, respectively. Increased Bcl-2 expression in primary tumours significantly correlated with favourable prognostic factors, namely pT1, G2 and lack of metastases to the regional lymph nodes (p < 0.01, p < 0.03, p < 0.02, respectively). There were no relationships between Bak and the clinicopathological features studied, but our results indicate changes in the expression of Bak during breast cancer development and progression. It would appear to be important to assess and compare pro- and anti-apoptotic proteins between normal mammary gland, benign mammary dysplasia and the primary tumours of breast cancer. This knowledge should be helpful in understanding breast cancer development and progression.
3

Comparison of plasma corticosterone concentration, muscle fibre diameter, and apoptotic markers between normal and pale, soft, exudative (PSE) turkey breast muscles

80%
Gorska M., Wojtysiak D.
Medycyna Weterynaryjna
|
2018
|
tom 74
|
nr 06
The increasing production potential of birds is correlated with a lower health and immune potential, resulting in the appearance of numerous meat quality defects. The greatest concern for gallinaceous poultry (chickens and turkeys) is PSE meat, which is characterized by light colour, soft texture and a reduced water-binding capacity. The aim of the study was to compare plasma corticosterone concentration, muscle fibre diameter, and the apoptotic markers between normal and pale, soft, exudative (PSE) turkey breast muscles. The results show, that the PSE group is characterized by a significantly higher plasma corticosterone concentration and a significantly greater muscle fibre diameter at 30 min post mortem compared to the normal group. The time of refrigerated storage (4°C) of meat contributes significantly to reducing muscle fibre diameter in the PSE group at 24 h post mortem compared to 30 min post mortem. Additionally, the results obtain showed that the caspase-3 activity at 30 min post mortem increased significantly in the turkey breast muscles of PSE compared with the normal group. Moreover, the PSE group demonstrated the higher apoptotic potential measured in the breast muscle of turkey compared with the normal group. It is stated from the obtained results that the incidence of PSE meat in turkeys may be associated with their higher susceptibility to stress factors and stressinduced pathological states.
4

Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers

80%
Koda M., Sulkowska M., Kanczuga-Koda L., Jarzabek K., Sulkowski S.
Folia Histochemica et Cytobiologica. Supplement
|
2007
|
tom 45
|
nr 1
187-191
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