Wyniki wyszukiwania

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Elevated serum osteoprotegerin is associated with decreased osteoclastic differentiation in stenotic aortic valves

100%

Lis G. J., Czubek U., Jasinska M., Jasek E., Laboda A., Dulak J., Nessler J., Sadowski J., Litwin J. A.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

2

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Heart rate turbulence in mild-to-moderate aortic stenosis in boxers

86%

Noszczyk-Nowak A.

Polish Journal of Veterinary Sciences

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2012

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tom 15

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nr 3

Heart rate turbulence (HRT) is a new electrocardiographic parameter used in human medicine to predict the possibility of death in patients with cardiac diseases. There is no information about HRT in healthy dogs and those with cardiac diseases. The aim of the present study was to compare the HRT in healthy Boxers dogs with Boxers with mild and moderate subaortic stenosis (SAS), to disclose the relationship between HRT and specific echocardiographic parameters and to evaluate if HRT can be used as a prognostic value in dogs with aortic stenosis. The study revealed significantly lower values of turbulence onset (TO) and turbulence slope (TS) HRT dogs with SAS (TO = -0.76 ± 2.6, TS = 7.1 ± 3.21) in compared with healthy dogs (TO = -7.45 ± 9.72, TS = 14.33 ± 8.76). TO values correlated with the left ventricular mass (LVM)/body mass factor (r = 0,32; p = 0.048). Based on the results obtained it can be stated that dogs with SAS have a compromised baroreceptor response, which can influence the mortality of the animals with described cardiac defect.

3

Serum RANTES, transforming growth factor-beta1, and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis

72%

Podolec J., Baran J., Siedlinski M., Urbanczyk M., Krupinski M., Bartus K., Niewiara L., Podolec M., Guzik T., Tomkiewicz-Pajak L., Komar M., Kablak-Ziembicka A.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 4

4

Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy

58%

Zheng L., Xu J., Qiu W., Liu X., Zhao C.-M., Chen D., Chen Y.

Journal of Physiology and Pharmacology

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2010

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tom 61

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nr 1

13-20

Pre-operative treatment with recombinant human erythropoietin may improve aortic stenosis patients' condition, including anemia and/or cardiac dysfunction, for subjecting to aortic valve replacement. In this study, we tested this hypothesis in a mouse model of aortic stenosis. Adult male mice were subjected to either aortic stenosis created by aortic ligature or sham operation. Aortic stenosis for 4 weeks caused cardiac hypertrophy, pulmonary congestion and left ventricular dysfunction. It was associated with increased levels of tumor necrosis factor-a in serum and myocardium, and reduced levels of interleukin-10 in myocardium but not in serum. Mytocyte apoptosis rate, level of cleaved caspase 3, activity of nuclear factor-B and expression of p38-MAPK pathway were also elevated. Erythropoietin treatment increased hematocrit but did not prevent the development of cardiac hypertrophy. It, however, reduced the apoptosis, prevented the increases in tumor necrosis factor-, nuclear factor-B activation and phosphorylation of p38, and attenuated the increases in lung weight, the decreases in LVEF and LVFS, and the increases in LVDd and LVDs. In conclusion recombinant human erythropoietin has cardioprotective effects in maladaptive cardiac hypertrophy by inhibiting nuclear factor-B activation, phosphorylation of p38-MAPK pathway, and production of tumor necrosis factor-, together leading to a reduced apoptosis.

Ograniczanie wyników

Elevated serum osteoprotegerin is associated with decreased osteoclastic differentiation in stenotic aortic valves

Heart rate turbulence in mild-to-moderate aortic stenosis in boxers

Serum RANTES, transforming growth factor-beta1, and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis

Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy