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In situ hybridization of two nodule-specific gene products from yellow lupin

100%

Olszewska M. J., Karlowski W., Legocki A. B.

Folia Histochemica et Cytobiologica

1994

tom 32

nr 3

The inhibition of in vivo tumorigenesis of osteosarcoma [OS]-732 cells by antisense human osteopontin RNA

84%

Liu S. J., Zhang D.-Q., Sui X.-M., Zhang L., Cai Z.-W., Sun L.-Q., Liu Y.-J., Xue Y., Hu G.-F.

Cellular and Molecular Biology Letters

2008

tom 13

nr 1

11-19

Osteopontin (OPN) is a secreted, non-collagenous, sialic acid-rich protein which functions by mediating cell-matrix interactions and cellular signaling via binding with integrins and CD44 receptors. An increasing number of studies have shown that OPN plays an important role in controlling cancer progression and metastasis. OPN was found to be expressed in many human cancer types, and in some cases, its over-expression was shown to be directly associated with poor patient prognosis. In vitro cancer cell line and animal model studies have clearly indicated that OPN can function in regulating the cell signaling that ultimately controls the oncogenic potential of various cancers. Previous studies in our laboratory demonstrated that OPN is highly expressed in human osteosarcoma (OS) cell line OS-732. In this study, we successfully reduced the tumorigenecity of OS-732 cells xenotransplanted into nude mice, using the antisense human OPN (hOPN) RNA expression vector.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Folia Histochemica et Cytobiologica

1 Cai Z.-W.

1 Hu G.-F.

1 Karlowski W.

1 Legocki A. B.

1 Liu S. J.

1 Liu Y.-J.

1 Olszewska M. J.

1 Sui X.-M.

1 Sun L.-Q.

1 Xue Y.

1 Zhang D.-Q.

1 Zhang L.

1 2008

1 1994

Wyniki wyszukiwania

In situ hybridization of two nodule-specific gene products from yellow lupin

The inhibition of in vivo tumorigenesis of osteosarcoma [OS]-732 cells by antisense human osteopontin RNA