Wyniki wyszukiwania

1

Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance

100%

Dajani E. Z., Shahwan T. G., Dajani N. E.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 6

2

Effect of curcumin on atherosclerosis in apoE-LDLR - double knockout mice

100%

Olszanecki R., Jawien J., Gajda M., Mateuszuk L., Gebska A., Korabiowska M., Chlopicki S., Korbut R.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 4

It is widely appreciated that inflammation and oxidant stress contribute to atherogenesis. Curcumin, a polyphenolic natural compound has been reported to possess anti-inflammatory and anti-oxidant actions. We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR - double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid). Curcumin (purity 98%), premixed with diet, was given for 4 months at a dose of 0.3 mg/per day/per mouse. In this model curcumin inhibited atherogenesis, measured both by "en face" method (25,15±2,9% vs. 19,2±0,6%, p<0,05) and "cross-section" method (565867±39764 µm2 vs. 299201±20373 µm2, p<0,05). Importantly, curcumin influenced neither the concentrations of cholesterol and triglycerides in blood nor animal body weight. To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR - double knockout mice.

3

Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis

80%

Celinski K., Dworzanski T., Fornal R., Korolczuk A., Madro A., Slomka M.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

4

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice

80%

Boban Blagaic A., Turcic P., Blagaic V., Dubovecak M., Jelovac N., Zemba M., Radic B., Becejac T., Stancic Rokotov D., Sikiric P.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 7

5

Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDs

70%

Suleyman H., Halici Z., Cadirci E., Hacimuftuoglu A., Bilen H.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 4

661-672

In this study we investigated both intact and adrenalectomized rats to determine whether or not the anti-inflammatory effects of indomethacin, diclofenac sodium, ibuprofen, nimesulide, tenoxicam and aspirin (IDINTA) are related to adrenal gland hormones in carrageenan-induced inflammation model of rats. Also, we investigated the anti-inflammatory action mechanism of hormones (adrenalin, cortisol) which perform a role in the anti-inflammatory effect of IDINTA on the adrenergic receptors. The results show that IDINTA produces significant anti-inflammatory effects in intact rats (ID50: 9.82, 10.81, 95.21, 75.23, 8.21 and 61.84 mg/kg), but insignificant effects in adrenalectomized rats (ID50: 152.97, 188.17, 1275.0, 433.67, 188.16 and 1028.17 mg/kg). In addition, adrenalin and prednisolone caused anti-inflammatory effect rates of 78.3% and 95.7% respectively in adrenalectomized rats. The anti-inflammatory effects of adrenalin and prednisolone did not change when prazosin (1-receptor blocker), yohimbine (2-receptor blocker) and phenoxybenzamine (1- and 2- receptor blocker) were given to rat groups; however, in adrenalectomized rats administered with propranolol (a non-selective blocker of ß1 and ß2-receptors) the anti-inflammatory effect of adrenalin was lost, and that of prednisolone decreased to 36.2%. It was also found that metoprolol (a selective blocker of ß1-receptors) did not alter the anti-inflammatory effects of the drugs. As a result, it was shown that anti-inflammatory effects of IDINTA are related to adrenalin and cortisol (corticosterone in rats). It was also determined for the first time that adrenalin (totally) and prednisolone (partially) triggered anti-inflammatory effects via the ß2-receptors but not via the 1, 2 and ß1-receptors.

Ograniczanie wyników

Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance

Effect of curcumin on atherosclerosis in apoE-LDLR - double knockout mice

Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice

Indirect role of beta2-adrenergic receptors in the mechanism of anti-inflammatory action of NSAIDs