Wyniki wyszukiwania

1

Investigating potential anxiolytic, antidepressant and memory enhancing activity of deprenyl

100%

Nowakowska E., Kus K., Chodera A., Rybakowska J.

Journal of Physiology and Pharmacology

|

2001

|

tom 52

|

nr 4,2

L-deprenyl in the dose of 0.25 mg/kg (the dose with no effect on locomotor activity) was administered to Wistar rats in single and prolonged treatment (21 days). In the same manner carboxymethyl cellulose was given to the control group. In the forced swimming test the rats from the deprenyl group showed reduced immobility time only once, after 7 days of treatment, as compared with the control group. In the Crawley’s test one parameter was increased after deprenyl — the white square entries (WSE), showing that the rats were emboldened to move more freely in the white, lighted area. In the maze test the most important observations were that deprenyl shortened the food finding time and significantly counteracted the elongation of this time after scopolamine. The authors discuss the possibility that deprenyl has a modulatory effect on learning and memory and this effect depends on the dose used. It seems also that the increase of monoamine and cholinergic transmission may be involved. The small antidepressant and anxiolytic effect may be due to the metabolites of deprenyl of the amphetamine group.

2

Synthetic antidepressants effect on proline accumulation and leaf structure in maize seedlings under salinity

84%

Chyzhykova O. A., Belyavskaya N. A., Palladina T. O.

Acta Physiologiae Plantarum

|

2007

|

tom 29

|

nr 1 Suppl.

3

Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors

84%

Rogoz Z., Wrobel A., Dlaboga D., Maj J., Dziedzicka-Wasylewska M.

Journal of Physiology and Pharmacology

|

2002

|

tom 53

|

nr 1

Mirtazapine (MIR)is an antidepressant which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagomism of central alpha2 - adrenergic autoreceptors and heteroreceptors.The drugs does not inhibit noradrenaline and serotonin reuptake but blocks the 5-HT2 and 5-HT3 receptors and has high affinity only for central and peripheral histamine H1 receptors.The present study was aimed at determining whether repeated MIR treatment induced adaptive changes in the alpha1 - adrenergic receptors,similar to those reported by us early for tricyclic antidepressants,The experiments were carried out on male mice and rats.MIR was administered at a dose of 10 mg/kg once or repeatedly (twice daily for 14 days).The obtained results showed that MIR administrated repeatedly potentiated the methoxamine-induced exploratory hyperactivity in rats and clonidine- induced aggressiveness in mice,those effects being mediated by alpha1 - adrenergic receptors. MIR given repeatedly (but not acutely)increased the binding (Bmax )of [3H ]prazosin to alpha1 - adrenergic receptors in cerebral cortex,however,the ability of the alpha1 - adrenoceptor agonist phenylephrine to compete for the these sites was not significantly changed.The above results indicate that repeated MIR administration increases the responsiveness of alpha1 - adrenergic system (behavioural and biochemical changes),as tricyclics do.However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy,remains open.

4

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward

67%

Fonberg E.

Acta Neurobiologiae Experimentalis

|

1992

|

tom 52

|

nr 2

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Acta Neurobiologiae Experimentalis

1 Acta Physiologiae Plantarum

1 Belyavskaya N. A.

1 Chodera A.

1 Chyzhykova O. A.

1 Dlaboga D.

1 Dziedzicka-Wasylewska M.

1 Fonberg E.

1 Kus K.

1 Maj J.

1 Nowakowska E.

1 Palladina T. O.

1 Rogoz Z.

1 Rybakowska J.

1 Wrobel A.

1 2007

1 2002

1 2001

1 1992

Investigating potential anxiolytic, antidepressant and memory enhancing activity of deprenyl

Synthetic antidepressants effect on proline accumulation and leaf structure in maize seedlings under salinity

Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward