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Inhibitory effect of resveratrol on free radical generation in blood platelets

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Olas B., Zbikowska H. M., Wachowicz B., Krajewski T., Buczynski A., Magnuszewska A.

Acta Biochimica Polonica

1999

tom 46

nr 4

Resveratrol (3,4',5-trihydroxystilbene), a compound found in many plants, has been shown to prevent coronary heart diseases and to exert a variety of antiinflammatory and anticancerogenic effects. It is effective in lowering the level of serum lipids and in inhibiting platelet aggregation. We evaluated the effect of trans-resveratrol on the production of free radicals in pig blood platelets and showed that resveratrol inhibited the production of different reactive oxygen species (O·2H2O2, singlet oxygen and organic radicals) measured by the luminol-dependent chemiluminescence in resting platelets (P < 0.05). Resveratrol inhibited also the generation of radicals in platelets activated by thrombin (P < 0.05). Treatment of platelets with resveratrol at concentrations of 6.25 and 12.5 μg/ml caused a statistically insignificant increase in the production of O·->2 in these cells, as measured by reduction of cytochrome c; however, at higher doses (25, 50 and 100μg/ml) resveratrol distinctly reduced the generation of O·->2 in platelets (P < 0.05). We suggest that free radicals play an important role in the reduced reactivity of blood platelets induced by resveratrol.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Buczynski A.

1 Krajewski T.

1 Magnuszewska A.

1 Olas B.

1 Wachowicz B.

1 Zbikowska H. M.

1 1999

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Inhibitory effect of resveratrol on free radical generation in blood platelets