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Bioactive compounds, antibacterial and antifungal activities of two Cirsium species

100%

Gulen D., Sabudak T., Orak H. H., Caliskan H., Ozer M.

Acta Scientiarum Polonorum. Hortorum Cultus

2019

tom 18

nr 5

In the GC-MS analysis, 81 bioactive phytochemical compounds were identified in hexane extracts of Cirsium creticum and Cirsium italicum. Terpenoids constituted the main fractions of C. italicum (70.95%), while hydrocarbons were most abundant compounds of C. creticum (41.11%). The antibacterial activity and antifungal activity of extracts from two Cirsium species was tested using microdilution methods. According to the results of antibacterial activity, the highest inhibition effect of C. creticum was found on B. subtilis, E. coli and P. aeruginosa. The highest inhibition effect of C. italicum was found on B. subtilis. In the results of antifungal activity, the highest inhibition effect of C. creticum was found on P. chrysogenum and the highest inhibition effect of C. italicum was found on C. krusei. The present work is the first report on hexane extracts compounds of two Cirsium species as well as antibacterial and antifungal activities.

The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design

67%

Piatek R., Zalewska B., Bury K., Kur J.

Acta Biochimica Polonica

2005

tom 52

nr 3

The chaperone-usher system determines the biogenesis of surface-exposed adhesive structures responsible for virulence of many Gram-negative bacteria. Investigations of the last 20 years have resolved the mechanism of this pathway on a structural level for different species of pathogenic bacteria. The purpose of this review is to present the molecular mechanisms of the biogenesis of adhesive structures assembled via the chaperone-usher pathway. The obtained mechanistic data allow one to propose potential strategies of anti-bacterial action. Additionally, the specific properties of the polymeric adhesive structures (pili and fimbriae) of the chaperone-usher system allow their use as effective and safe recombinant vaccines carrying foreign epitopes in thousands of copies on bacterial cell surface.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Acta Scientiarum Polonorum. Hortorum Cultus

1 Bury K.

1 Caliskan H.

1 Gulen D.

1 Kur J.

1 Orak H. H.

1 Ozer M.

1 Piatek R.

1 Sabudak T.

1 Zalewska B.

1 2019

1 2005

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Bioactive compounds, antibacterial and antifungal activities of two Cirsium species

The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design