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Determination of hippuric acid by RP-HPLC using two different analytical columns - a short report

100%

Pegg R. B., Rybarczyk A., Amarowicz R.

Polish Journal of Food and Nutrition Sciences

2007

tom 57

nr 4

447-450

Reversed-phase HPLC of liberated hippuric acid (HA) from an ACE assay in the presence of ACE inhibitory peptides derived from a crackling hydrolysate was conducted. The efficacies of two different analytical HPLC columns using identical mobile phases with an isocratic system were tested. Chromatograms revealed that the shorter C8 column (4.6 × 150 mm, 5 μm) was just as efficient as the longer C18 column (4.6 × 250 mm, 5 μm) in resolving liberated HA, but achieved this in a much shorter time (i.e., 3.67 cf 12.52 min). The presence of the crackling hydrolysate exhibited ACE-inhibiting activity by retarding the liberation of HA from the substrate hippuryl-L-histydyl-L-leucine (HHL) in a dose-dependent manner, and did not interfere with the chromatography. Hence, a quick reliable analytical methodology is at hand for the in vitro examination of various “bioactive peptide concoctions” for possible use in the development of functional foods.

Association of ACE DD genotype with Hypertension among the tribal populations of South India

100%

Paramasivam R., Nandakumar R., Arumugam D., Krishnan P.

International Letters of Natural Sciences

2016

tom 52

The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0 .705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

Genes and physical fitness

67%

Gronek P., Holdys J.

Trends in Sport Sciences

2013

tom 20

nr 1

The search for genes with that positively affect physical fitness is a difficult process. Physical fitness is determined by numerous genes, and its genetic determinants are modified by environmental factors. The map of candidate genes that can potentially affect physical fitness becomes larger every year, and currently it contains more than 200 genes associated with such aspects as respiratory and cardiovascular stability; body build and composition – especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exercise intolerance. The inclusion of the genetic component in physiological and biochemical studies would permit drawing a representation of predispositions for each athlete interested in practicing high performance sports and would be a valuable coaching aid in the process of training individualization.

Ograniczanie wyników

1 International Letters of Natural Sciences

1 Polish Journal of Food and Nutrition Sciences

1 Trends in Sport Sciences

1 Amarowicz R.

1 Arumugam D.

1 Gronek P.

1 Holdys J.

1 Krishnan P.

1 Nandakumar R.

1 Paramasivam R.

1 Pegg R. B.

1 Rybarczyk A.

1 2016

1 2013

1 2007

Wyniki wyszukiwania

Determination of hippuric acid by RP-HPLC using two different analytical columns - a short report

Association of ACE DD genotype with Hypertension among the tribal populations of South India

Genes and physical fitness